Pharmacological effects Mechanism of action Bioactivity
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Kaempferol

Pharmacological effects Mechanism of action Bioactivity
Product Name
Kaempferol
CAS No.
520-18-3
Chemical Name
Kaempferol
Synonyms
kaempherol;kempferol;KAEMPFEROL 98%;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;campherol;pelargidenolon;Kaempferol Hydrate;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,4';asurone
CBNumber
CB5223176
Molecular Formula
C15H10O6
Formula Weight
286.24
MOL File
520-18-3.mol
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Kaempferol Property

Melting point:
276°C
Boiling point:
348.61°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
1.4413 (estimate)
storage temp. 
2-8°C
solubility 
ethanol: 20 mg/mL
form 
powder
Colour Index 
75640
pka
6.34±0.40(Predicted)
color 
yellow
biological source
synthetic
Merck 
14,5274
BRN 
304401
Stability:
Unstable in Solution
InChIKey
IYRMWMYZSQPJKC-UHFFFAOYSA-N
LogP
2.685 (est)
CAS DataBase Reference
520-18-3(CAS DataBase Reference)
IARC
3 (Vol. 31, Sup 7) 1987
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-68-25
Safety Statements 
26-36-45-36/37-36/37/38-22
RIDADR 
2811
WGK Germany 
-
RTECS 
LK9275200
F 
8-10-23
HS Code 
29329990
Hazardous Substances Data
520-18-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2705
Product name
Kaempferol
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg
Packaging
30MG
Price
$408.5
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL89235
Product name
Kaempferol
Purity
phyproof? Reference Substance
Packaging
20MG
Price
$453
Updated
2025/07/31
Sigma-Aldrich
Product number
1354900
Product name
Kaempferol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$385
Updated
2025/07/31
Sigma-Aldrich
Product number
00550580
Product name
Kaempferol
Purity
primary reference standard
Packaging
10mg
Price
$497
Updated
2023/01/07
TCI Chemical
Product number
K0018
Product name
Kaempferol Hydrate
Purity
>97.0%(HPLC)
Packaging
1g
Price
$877
Updated
2025/07/31
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Kaempferol Chemical Properties,Usage,Production

Pharmacological effects

Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).

Mechanism of action

Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).

Bioactivity

As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.

Chemical Properties

Yellow Solid

Uses

antidepressant, inhibits fatty acid amide hydrolase

Uses

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Uses

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Definition

ChEBI: Kaempferol is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. It has a role as an antibacterial agent, a plant metabolite, a human xenobiotic metabolite, a human urinary metabolite, a human blood serum metabolite and a geroprotector. It is a member of flavonols, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a kaempferol oxoanion.

General Description

Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .

Biochem/physiol Actions

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

Anticancer Research

Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).

storage

Store at +4°C

Kaempferol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Kaempferol manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
Kaempferol 520-18-3
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-09-25
Shaanxi Xianhe Biotech Co., Ltd
Product
Kaempferol 520-18-3
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
1000KG
Release date
2025-04-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
Kaempferol 520-18-3
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2025-03-14

520-18-3, KaempferolRelated Search:

ARTEMISININ FLAVONE 7-HYDROXYFLAVONE Isoflavone Hydroxy silicone oil Chrysin KAEMPFERITRIN KAEMPFEROL-3-O-RUTINOSIDE,KAEMPFEROL-3-RUTINOSIDE Rotundine Quercetin dihydrate Sophoricoside Kaempferol 3-neohesperidoside 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one kaempferol-3-O-galactoside KaeMpferol-4'-O-β-D-glucopyranoside KaeMpferol 7-O-rhaMnoside KAEMPFEROL-3-GLUCURONIDE Kaempferol-3-O-(2,6-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside

  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
  • 5,7,4’-trihydroxyflavonol
  • c.i.75640
  • campherol
  • indigoyellow
  • kaempherol
  • kampherol
  • kempferol
  • nimbecetin
  • pelargidenolon
  • pelargidenolon1497
  • populnetin
  • rhamnolutein
  • rhamnolutin
  • swartziol
  • KAEMPFEROL
  • 3,5,7,4'-TETRAHYDROXYFLAVONE
  • 3,5,7-TRIHYDROXY-2-[4-HYDROXY-PHENYL]-4H-1-BENZOPYRAN-4-ONE
  • 3,4',5,7-TETRAHYDTOXYFLAVONE
  • ROBIGENIN
  • 3,4'
  • Kaempferol,3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
  • KAEMPFEROL(RG)(PLEASECALL)
  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one
  • KaeMpferol&nbsp
  • 4β-Hydroxy Cholesterol-d4 (Major)
  • NSC 407289
  • NSC 656277
  • Pelargidenon
  • Trifolitin
  • 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-
  • Kaempferol ,98%
  • Kaempferol, 98%, from Sophora japonica Linn.
  • Nano Liposomal Kaempferol
  • Kaempferol - CAS 520-18-3 - Calbiochem
  • Kaempferol 520-18-3
  • KAEMPFEROL(AMERICAN HERBAL PHARMACOPOEIA)
  • 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • KAEMPFERIDE(SH)
  • Kaempferol 97 % pure
  • KAEMPFEROL FROM GINKGO BILOBA LEAF 99+%(HPLC)
  • KAEMPFEROL 98%
  • KAEMPFEROL ROBIGENIN, 3,4',5,7-TETRAHYDRO-XY-FLAVONE
  • Rhamnoluteun
  • Robigenin/Kaempferol
  • asurone
  • KAEMPFEROL hplc
  • 3,4',5,7-Tetrahydroxyflavone
  • KAEMPFEROL ROBIGENIN
  • KAEMPFEROL WITH HPLC
  • 3,4μ,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
  • 4',5,7-Trihydroxyflavonol
  • Swartsiol
  • 3.5,7,4'-tetrahydroxyflavone Swartziol Trifolitin Nimbecetin Populnetin
  • Kaempferol Hydrate
  • KaempferolHydrate&gt
  • Kaempferol (3,4',5,7-Tetrahydroxyflavone)
  • 3,4'',5,7-Tetrahydroxyflavone hydrate