ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)phenylhydrazine hydrochloride

3-(Trifluoromethyl)phenylhydrazine hydrochloride

Product Name: 3-(Trifluoromethyl)phenylhydrazine hydrochloride
CAS No.: 3107-33-3
Chemical Name: 3-(Trifluoromethyl)phenylhydrazine hydrochloride
Synonyms: 3-Trifloromethylphenylhydrazine;3-TRIFLUOROMETHYL PHENYLHYDRAZINE HCL;3-Hydrazinobenzotrifluoride hydrochloride;3-Trifluoromethylphenylhydrazine hydrochlroide;3-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE;3-(Triflnoromethyl)phenl hydrazine hydrochloride;N'-(3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINIUM, CHLORIDE;3-(Trifluoromethyl)phenylhydrazine hydrochloride,98%;3107-33-3 3-(Trifluoromethyl)phenylhydrazine hydrochloride;Hydrazine, [3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)
CBNumber: CB5236640
Molecular Formula: C7H8ClF3N2
Formula Weight: 212.6
MOL File: 3107-33-3.mol

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3-(Trifluoromethyl)phenylhydrazine hydrochloride Property

Melting point:: 224-225 °C (decomp)
Boiling point:: 140℃/30mm
Density: 1.348
refractive index: 1.504 (20/D)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO, Methanol
form: Solid
color: Pale Yellow
Specific Gravity: 1.348
CAS DataBase Reference: 3107-33-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22
Safety Statements: 36/37-24/25
Hazard Note: Irritant
TSCA: N
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T797095
Product name: 3-(Trifluoromethyl)phenylhydrazineHydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T797095
Product name: 3-(Trifluoromethyl)phenylhydrazineHydrochloride
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: T797095
Product name: 3-(Trifluoromethyl)phenylhydrazineHydrochloride
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 290864
Product name: 3-Trifluoromethyl phenylhydrazine HCl
Packaging: 5g
Price: $369
Updated: 2021/12/16

Ark Pharm

Product number: AK-47293
Product name: (3-(Trifluoromethyl)phenyl)hydrazinehydrochloride
Purity: 97%
Packaging: 5g
Price: $8
Updated: 2021/12/16

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3-(Trifluoromethyl)phenylhydrazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

3-Trifluoromethylphenylhydrazine Hydrochloride, is an intermediate in the synthesis of pharmaceutical compounds including inhibitors, and anticancer agents. It is used in the synthesis of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents.

Synthesis

401-78-5

3107-33-3

General procedure for the synthesis of 3-trifluoromethylphenylhydrazine hydrochloride from m-bromobenzotrifluoride: CuBr (36 mg, 0.25 mmol, 2.5 mol%), ligand L3 (110 mg, 0.4 mmol, 4 mol%), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol) were added and mixed in a 15 mL screw-top capped test tube. STAC (110 mg, 0.3 mmol, 3 mol%) and m-bromobenzotrifluoride (10 mmol) were then added, and the resulting mixture was stirred at 80-110°C (oil bath temperature) for 10 min. Next, K3PO4 (2.29 g, 10.8 mmol) and N2H4-H2O (1 g, 20 mmol) were added and argon gas (flow rate 5-7 mL/min) was bubbled through the reaction mixture for 5 min. The reaction mixture was stirred in a closed test tube at 80-110°C (oil bath temperature) for 1-2 h. The progress of the reaction was monitored by TLC (eluent: hexane) until the feedstock was completely consumed. After completion of the reaction, it was cooled to room temperature and diluted with dichloromethane (50 mL). The resulting solution was filtered and washed with saturated saline (225 mL). A 37% aqueous HCl solution was added dropwise to the dichloromethane solution until the pH reached 3-4. The precipitate formed was filtered, washed with dichloromethane (15 mL) and dried at room temperature. NMR spectra of the partially synthesized 3-trifluoromethylphenylhydrazine hydrochloride showed the presence of 1-5 mol% of the corresponding aniline hydrochloride as an impurity (see Supplementary Data). To obtain an analytically pure sample, it can be purified by precipitation by adding 2-3 volumes of diethyl ether from a methanol solution.

References

[1] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[2] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048

3-(Trifluoromethyl)phenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(Trifluoromethyl)phenylhydrazine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(Trifluoromethyl)phenylhydrazine hydrochloride 3107-33-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-11

Career Henan Chemical Co

Product: 3-(Trifluoromethyl)phenylhydrazine hydrochloride 3107-33-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-20

3107-33-3, 3-(Trifluoromethyl)phenylhydrazine hydrochlorideRelated Search:

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3-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE

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3-TRIFLUOROMETHYL PHENYLHYDRAZINE HCL

3-(Trifluoromethyl)phenylhydrazine hydrochloride,98%

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3-Trifloromethylphenylhydrazine

3-Trifluoromethylphenylhydrazine hydrochlroide

3-Hydrazinobenzotrifluoride hydrochloride

3-Hydrazinobenzotrifluoride hydrochloride, 1-Hydrazino-3-(trifluoromethyl)benzene hydrochloride

Hydrazine, [3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)

3107-33-3 3-(Trifluoromethyl)phenylhydrazine hydrochloride

3107-33-3