4-Methylphenylhydrazine hydrochloride

Product Name: 4-Methylphenylhydrazine hydrochloride
CAS No.: 637-60-5
Chemical Name: 4-Methylphenylhydrazine hydrochloride
Synonyms: P-TOLYLHYDRAZINE HYDROCHLORIDE;P-METHYLPHENYLHYDRAZINE HYDROCHLORIDE;Tolyl Hydrazine Hcl;4-TOLYLHYDRAZINE HCL;P-TOLYL HYDRAZINE HCL;PARA-TOLYLHYDRAZINEHCL;p-tolylhydrazine HCl salt;4-METHYLPHENYLHYDRAZINE HCL;p-tolyl-hydrazinhydrochloride;p-tolyhydrazine hydrochloride
CBNumber: CB3178719
Molecular Formula: C7H11ClN2
Formula Weight: 158.63
MOL File: 637-60-5.mol

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4-Methylphenylhydrazine hydrochloride Property

Melting point:: >200 °C (dec.)(lit.)
Boiling point:: 217.6°C (rough estimate)
Density: 0.9532 (rough estimate)
refractive index: 1.6230 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol
form: Flaky Powder
color: Off-white to beige-brownish
Water Solubility: soluble
Merck: 14,9542
BRN: 3563996
CAS DataBase Reference: 637-60-5(CAS DataBase Reference)
EPA Substance Registry System: Hydrazine, (4-methylphenyl)-, monohydrochloride (637-60-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-40
Safety Statements: 26-36-36/37/39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MW0195000
Hazard Note: Harmful/Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H350May cause cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T40606
Product name: p-Tolylhydrazine hydrochloride
Purity: 98%
Packaging: 25g
Price: $155
Updated: 2025/07/31

TCI Chemical

Product number: T0319
Product name: p-Tolylhydrazine Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: T0319
Product name: p-Tolylhydrazine Hydrochloride
Purity: >98.0%(T)
Packaging: 250g
Price: $197
Updated: 2021/12/16

TRC

Product number: T536610
Product name: 4-TolylhydrazineMonohydrochloride
Packaging: 10g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3739-5-X4
Product name: 4-Methylphenylhydrazine hydrochloride
Purity: 98%
Packaging: 100g
Price: $192
Updated: 2021/12/16

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4-Methylphenylhydrazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

off-white to beige-brownish flaky powder

Uses

4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.

Synthesis

106-49-0

637-60-5

General procedure for the synthesis of 4-methylphenylhydrazine hydrochloride from 4-methylaniline: 4-methylaniline (10.7 g, 0.1 mol) was mixed with dilute hydrochloric acid in a 200 ml round bottom flask. Sodium nitrite solution (30 ml, 7.3 g, 0.105 mol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred for 1 hour and then filtered. The filtered clear liquid was added dropwise to 70 ml of aqueous solution containing sodium sulfite (37.8 g, 0.3 mol) and reacted at 80°C for about 1.5 hours. Subsequently, concentrated hydrochloric acid (25 ml, 0.3 mol) was added slowly and the reaction temperature was raised to 95°C and the reaction continued for about 2.5 hours. Upon completion of the reaction, the mixture was allowed to stand at room temperature overnight to precipitate 4-methylphenylhydrazine hydrochloride as a solid. After filtration and drying, 12.9 g of product was obtained in 90.0% yield.

References

[1] Patent: CN108623511, 2018, A. Location in patent: Paragraph 0021
[2] Patent: EP2157088, 2010, A1. Location in patent: Page/Page column 41-42
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1706 - 1712

4-Methylphenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

5-Methyl-L-tryptophan

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4-Methylphenylhydrazine hydrochloride Suppliers

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View Lastest Price from 4-Methylphenylhydrazine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Methylphenylhydrazine hydrochloride 637-60-5
Price: US $50.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-05

Henan Fengda Chemical Co., Ltd

Product: 4-Methylphenylhydrazine hydrochloride 637-60-5
Price: US $10.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Methylphenylhydrazine hydrochloride 637-60-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

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Organic Building Blocks

Nitrogen Compounds

Hydrazines

HYDRAZINE

Building Blocks

Chemical Synthesis

Hydrazines

Nitrogen Compounds

Organic Building Blocks

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes

Phenylhydrazine

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