5-METHOXY-PYRIDIN-3-OL
- Product Name
- 5-METHOXY-PYRIDIN-3-OL
- CAS No.
- 109345-94-0
- Chemical Name
- 5-METHOXY-PYRIDIN-3-OL
- Synonyms
- 5-METHOXY-PYRIDIN-3-OL;3-Pyridinol, 5-methoxy-;3-HYDROXY-5-METHOXYPYRIDINE;3-Pyridinol,5-methoxy-(9CI);5-Methoxypyridin-3-ol,95%,PY-7888;5-METHOXY-PYRIDIN-3-OL ISO 9001：2015 REACH;5-
Methoxy- pyridin- 3- ol;5-Methoxypyridin-3-ol, 5-Hydroxypyridin-3-yl methyl ether - CBNumber
- CB5237531
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 109345-94-0.mol
5-METHOXY-PYRIDIN-3-OL Property
- Melting point:
- 147.5-148.5 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 346.7±22.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.93±0.10(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000384
- Product name
- 5-Methoxy-pyridin-3-ol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $463
- Updated
- 2023/01/07
- Product number
- M267105
- Product name
- 5-Methoxypyridin-3-ol
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- M267105
- Product name
- 5-Methoxypyridin-3-ol
- Packaging
- 2.5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 4H56-1-V5
- Product name
- 3-Hydroxy-5-methoxypyridine
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
- Product number
- 4H56-1-V5
- Product name
- 3-Hydroxy-5-methoxypyridine
- Packaging
- 5G
- Price
- $568
- Updated
- 2021/12/16
5-METHOXY-PYRIDIN-3-OL Chemical Properties,Usage,Production
Chemical Properties
Off white powder
Uses
5-Methoxypyridin-3-ol is patented as a reagent to prepare various compounds as nicotinic receptor ligands.
Synthesis
445264-60-8
109345-94-0
The general procedure for the synthesis of 5-methoxy-3-hydroxypyridine from 5-methoxy-3-pyridine pinacol borate was as follows: to a stirred suspension of sodium perborate tetrahydrate (7.86 g, 51.06 mmol) in water was added 3-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (4 g. 17.02 mmol) solution of THF/H2O (80 mL:80 mL) and the reaction was carried out at room temperature. The resulting reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (200 mL), followed by washing the organic layer with brine and drying over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 20% ethyl acetate as eluent to give a final product of 1.5 g of 5-methoxypyridin-3-ol. LCMS analysis showed a molecular ion peak of 126 (M+H). Step 3 involved the conversion of 3-methoxy-5-hydroxypyridine to 3-methoxy-5-methoxymethoxypyridine.
References
[1] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 156; 157
5-METHOXY-PYRIDIN-3-OL Preparation Products And Raw materials
Raw materials
Preparation Products
5-METHOXY-PYRIDIN-3-OL Suppliers
- Tel
- --
- Fax
- --
- info@chemstep.com
- Country
- Europe
- ProdList
- 6143
- Advantage
- 51
View Lastest Price from 5-METHOXY-PYRIDIN-3-OL manufacturers
- Product
- 5-METHOXY-PYRIDIN-3-OL 109345-94-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- 5-METHOXY-PYRIDIN-3-OL 109345-94-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-18