ChemicalBook > CAS DataBase List > 2-AMINO-BETA-NAPHTHOTHIAZOLE

2-AMINO-BETA-NAPHTHOTHIAZOLE

Product Name
2-AMINO-BETA-NAPHTHOTHIAZOLE
CAS No.
40172-65-4
Chemical Name
2-AMINO-BETA-NAPHTHOTHIAZOLE
Synonyms
SKA 31;-2-amine;AKOS BBS-00006561;IFLAB-BB F1386-0401;naphtho[1,2-d]thiazoL;SKA-31, 10 mM in DMSO;LABOTEST-BB LT00154570;2-Amino-β-naphthothiazole;2-AMINONAPHTHO-1,2-THIAZOLE;2-AMINO-BETA-NAPHTHOTHIAZOLE
CBNumber
CB5244427
Molecular Formula
C11H8N2S
Formula Weight
200.26
MOL File
40172-65-4.mol
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2-AMINO-BETA-NAPHTHOTHIAZOLE Property

Melting point:
184-188°C
Boiling point:
417.1±28.0 °C(Predicted)
Density 
1.403±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: ≥30mg/mL
form 
solid
pka
3.50±0.30(Predicted)
color 
Off-white
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference
40172-65-4(CAS DataBase Reference)
EPA Substance Registry System
Naphtho[1,2-d]thiazol-2-amine (40172-65-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-36-22
Safety Statements 
22-36/37/39-26
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5576
Product name
SKA-31
Purity
≥98% (HPLC)
Packaging
5mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
S5576
Product name
SKA-31
Purity
≥98% (HPLC)
Packaging
25mg
Price
$721
Updated
2024/03/01
Cayman Chemical
Product number
29690
Product name
SKA-31
Packaging
5mg
Price
$53
Updated
2024/03/01
Cayman Chemical
Product number
29690
Product name
SKA-31
Packaging
10mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
29690
Product name
SKA-31
Packaging
25mg
Price
$213
Updated
2024/03/01
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2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Usage,Production

Description

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Biological Activity

Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

storage

+4°C

References

Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60

2-AMINO-BETA-NAPHTHOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-BETA-NAPHTHOTHIAZOLE Suppliers

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40172-65-4, 2-AMINO-BETA-NAPHTHOTHIAZOLERelated Search:

PF-01367338 ML335 NOTUMib-1 Levetiracetam 2'-Deoxyadenosine Bithionol Octamethylcyclotetrasiloxane Perfecta3D hanging drop plate ALPHA-AMINO-BETA-NAPHTHOTHIAZOLE IFLAB-BB F1386-0362 Rifamexil 2-AMINO-BETA-NAPHTHOTHIAZOLE

  • NAPHTHO[1,2-D][1,3]THIAZOL-2-AMINE
  • NAPHTHO[1,2-D]THIAZOL-2-YLAMINE
  • 2-AMINO-BETA-NAPHTHOTHIAZOLE
  • 2-AMINO-NAPHTHO[1,2-D]THIAZOLE
  • 2-AMINONAPHTHO-1,2-THIAZOLE
  • AKOS BBS-00006561
  • IFLAB-BB F1386-0401
  • LABOTEST-BB LT00154570
  • naphtho[1,2-d]thiazol-2-amine
  • Naphtho[1,2-d]thiazol-2-amine (9CI)
  • 2-Amino-β-naphthothiazole
  • SKA 31
  • 2-(2-amino-5,6-dihydro-4H-pyrimidin-1-yl)acetic acid
  • -2-amine
  • naphtho[1,2-d]thiazoL
  • Naphtho[1,2-d]thiazol-2(1H)-imine
  • benzo[e][1,3]benzothiazol-2-amine
  • inhibit,Potassium Channel,SKA-31,KcsA,Inhibitor
  • SKA-31, 10 mM in DMSO
  • 40172-65-4
  • BENZOTHIAZOLE