ChemicalBook > CAS DataBase List > 2-AMINO-BETA-NAPHTHOTHIAZOLE
2-AMINO-BETA-NAPHTHOTHIAZOLE
- Product Name
- 2-AMINO-BETA-NAPHTHOTHIAZOLE
- CAS No.
- 40172-65-4
- Chemical Name
- 2-AMINO-BETA-NAPHTHOTHIAZOLE
- Synonyms
- SKA 31;-2-amine;AKOS BBS-00006561;IFLAB-BB F1386-0401;naphtho[1,2-d]thiazoL;LABOTEST-BB LT00154570;2-Amino-β-naphthothiazole;2-AMINONAPHTHO-1,2-THIAZOLE;2-AMINO-BETA-NAPHTHOTHIAZOLE;naphtho[1,2-d]thiazol-2-amine
- CBNumber
- CB5244427
- Molecular Formula
- C11H8N2S
- Formula Weight
- 200.26
- MOL File
- 40172-65-4.mol
More
Less
2-AMINO-BETA-NAPHTHOTHIAZOLE Property
- Melting point:
- 184-188°C
- Boiling point:
- 417.1±28.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: ≥30mg/mL
- form
- solid
- pka
- 3.50±0.30(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 40172-65-4(CAS DataBase Reference)
- EPA Substance Registry System
- Naphtho[1,2-d]thiazol-2-amine (40172-65-4)
More
Less
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-36-22
- Safety Statements
- 22-36/37/39-26
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S5576
- Product name
- SKA-31
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S5576
- Product name
- SKA-31
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $721
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 5mg
- Price
- $53
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 25mg
- Price
- $213
- Updated
- 2024/03/01
More
Less
2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Usage,Production
Description
SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3
Biological Activity
Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
storage
+4°C
References
Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60
2-AMINO-BETA-NAPHTHOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-AMINO-BETA-NAPHTHOTHIAZOLE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 822
- Advantage
- 65
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 13817485796
- Fax
- QQ:895624079
- tim@wisacheampharm.com
- Country
- China
- ProdList
- 3710
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 3501
- Advantage
- 55
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 0371-60919097 15378766539
- Fax
- 0371-60919097
- 794449696@qq.com
- Country
- China
- ProdList
- 5006
- Advantage
- 58
- Tel
- 025-66110311 13155353615
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15527
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49391
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49323
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- +86-021-61551413 +8618813727289
- contact@trustwe.com
- Country
- China
- ProdList
- 5738
- Advantage
- 58
- Tel
- 2537653158 16621191650
- Fax
- QQ 2537653158
- 2537653158@qq.com
- Country
- China
- ProdList
- 7362
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31163
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
- Country
- China
- ProdList
- 61720
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6712
- Advantage
- 58
- Tel
- 17691182729 18161915376
- 1046@dideu.com
- Country
- China
- ProdList
- 10010
- Advantage
- 58
- Tel
- 0573-85609002
- zhejia01@163.com
- Country
- China
- ProdList
- 8871
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24023
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 9919
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 3001
- Advantage
- 58
- Tel
- 029-81310890 13571859809
- info@pushanshiye.com
- Country
- China
- ProdList
- 10004
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50471
- Advantage
- 58
- Tel
- 021-57520305 13764600721
- wangkang@jskchem.com
- Country
- China
- ProdList
- 49036
- Advantage
- 58
- Tel
- 029-029-2148545164 17392779578
- 2148545164@qq.com
- Country
- China
- ProdList
- 6798
- Advantage
- 58
- Tel
- 15552437730
- 1701654643@qq.com
- Country
- China
- ProdList
- 11375
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9180
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32686
- Advantage
- 60
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43348
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3007606172@qq.com
- Country
- CHINA
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6942
- Advantage
- 58
- Tel
- --
- Fax
- --
- yangmei@bioneeds.net
- Country
- CHINA
- ProdList
- 6999
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1920192055@qq.com
- Country
- CHINA
- ProdList
- 1843
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- 912529879@qq.com
- Country
- CHINA
- ProdList
- 6852
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6921
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6652
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6979
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6172
- Advantage
- 58
40172-65-4, 2-AMINO-BETA-NAPHTHOTHIAZOLERelated Search:
PF-01367338
ML335
NOTUMib-1
Levetiracetam
2'-Deoxyadenosine
Bithionol
Octamethylcyclotetrasiloxane
Perfecta3D hanging drop plate
ALPHA-AMINO-BETA-NAPHTHOTHIAZOLE
IFLAB-BB F1386-0362
Rifamexil
2-AMINO-BETA-NAPHTHOTHIAZOLE