2-AMINO-BETA-NAPHTHOTHIAZOLE
- Product Name
- 2-AMINO-BETA-NAPHTHOTHIAZOLE
- CAS No.
- 40172-65-4
- Chemical Name
- 2-AMINO-BETA-NAPHTHOTHIAZOLE
- Synonyms
- SKA 31;-2-amine;AKOS BBS-00006561;IFLAB-BB F1386-0401;naphtho[1,2-d]thiazoL;LABOTEST-BB LT00154570;2-Amino-β-naphthothiazole;2-AMINONAPHTHO-1,2-THIAZOLE;2-AMINO-BETA-NAPHTHOTHIAZOLE;naphtho[1,2-d]thiazol-2-amine
- CBNumber
- CB5244427
- Molecular Formula
- C11H8N2S
- Formula Weight
- 200.26
- MOL File
- 40172-65-4.mol
2-AMINO-BETA-NAPHTHOTHIAZOLE Property
- Melting point:
- 184-188°C
- Boiling point:
- 417.1±28.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: ≥30mg/mL
- form
- solid
- pka
- 3.50±0.30(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 40172-65-4(CAS DataBase Reference)
- EPA Substance Registry System
- Naphtho[1,2-d]thiazol-2-amine (40172-65-4)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-36-22
- Safety Statements
- 22-36/37/39-26
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- S5576
- Product name
- SKA-31
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- S5576
- Product name
- SKA-31
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $721
- Updated
- 2024/03/01
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 5mg
- Price
- $53
- Updated
- 2024/03/01
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 29690
- Product name
- SKA-31
- Packaging
- 25mg
- Price
- $213
- Updated
- 2024/03/01
2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Usage,Production
Description
SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3
Biological Activity
Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
storage
+4°C
References
Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60