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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL

Product Name
(6-BROMO-NAPHTHALEN-2-YL)-METHANOL
CAS No.
100751-63-1
Chemical Name
(6-BROMO-NAPHTHALEN-2-YL)-METHANOL
Synonyms
6-bromo-2-naphthalinol;6-BroMo-2-naphthaleneMethanol;2-NAPHTHALENEMETHANOL, 6-BROMO-;(6-BROMO-NAPHTHALEN-2-YL)-METHANOL
CBNumber
CB52451689
Molecular Formula
C11H9BrO
Formula Weight
237.09
MOL File
100751-63-1.mol
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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Property

Melting point:
152-153℃
Boiling point:
374.6±17.0 °C(Predicted)
Density 
1.544±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DCM, DMSO. DMF, Ethyl Acetate
form 
Solids
pka
14.15±0.10(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B685935
Product name
6-Bromo-2-naphthalenemethanol
Packaging
10g
Price
$130
Updated
2021/12/16
Usbiological
Product number
162099
Product name
6-Bromo-2-naphthalenemethanol
Packaging
10g
Price
$425
Updated
2021/12/16
TRC
Product number
B685935
Product name
6-Bromo-2-naphthalenemethanol
Packaging
100g
Price
$605
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0063777
Product name
(2-BROMONAPHTHALEN-6-YL)METHANOL
Purity
95.00%
Packaging
5MG
Price
$495.32
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
55062
Product name
6-Bromo-2-naphthalenemethanol
Packaging
25g
Price
$725
Updated
2021/12/16
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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Chemical Properties,Usage,Production

Uses

6-Bromo-2-naphthalenemethanol is an intermediate in the synthesis of Adapalene (A225000), an antiacne agent.

Synthesis

5773-80-8

100751-63-1

General procedure for the synthesis of 6-bromo-2-hydroxymethylnaphthalene from 6-bromo-2-naphthalenecarboxylic acid: To a solution of 6-bromo-2-naphthalenecarboxylic acid (1 g, 3.98 mmol) in tetrahydrofuran (THF, 20 ml) was added a tetrahydrofuran solution of 2M borane dimethyl sulphide (0.53 ml, 5.97 mmol) in batches at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the mixture was cooled to 0°C and the reaction was quenched by addition of methanol (MeOH). Subsequently, the solution was concentrated under reduced pressure. The crude product was purified by column chromatography (using ethyl acetate in heptane as eluent) to afford 6-bromo-2-hydroxymethylnaphthalene (0.4 g, 89% yield). lCMS analysis showed m/z 238 [M + H]+ .

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 267 - 273
[2] Patent: WO2009/130475, 2009, A1. Location in patent: Page/Page column 31-32
[3] Patent: WO2016/40891, 2016, A2. Location in patent: Paragraph 00335
[4] Patent: WO2005/40157, 2005, A2. Location in patent: Page/Page column 83
[5] Patent: WO2016/112284, 2016, A1. Location in patent: Page/Page column 132; 133

(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Suppliers

China 71 India 4 United States 8 Global 83
Alfa Chemistry
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View Lastest Price from (6-BROMO-NAPHTHALEN-2-YL)-METHANOL manufacturers

Shanghai Rlavie Technology Co ltd
Product
6-Bromo-2-naphthylmethanol 100751-63-1
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
100kgs/month
Release date
2021-11-04
Career Henan Chemical Co
Product
(6-BROMO-NAPHTHALEN-2-YL)-METHANOL 100751-63-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

100751-63-1, (6-BROMO-NAPHTHALEN-2-YL)-METHANOLRelated Search:

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  • 6-BroMo-2-naphthaleneMethanol
  • 2-NAPHTHALENEMETHANOL, 6-BROMO-
  • 6-bromo-2-naphthalinol
  • 100751-63-1