PI 828
- Product Name
- PI 828
- CAS No.
- 942289-87-4
- Chemical Name
- PI 828
- Synonyms
- PI 828;PI 828,PI828;LY 294002, 4′-NH2;LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem;8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one;8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-(4-aminophenyl)-2-(4-morpholinyl)-
- CBNumber
- CB52455753
- Molecular Formula
- C19H18N2O3
- Formula Weight
- 322.36
- MOL File
- 942289-87-4.mol
PI 828 Property
- Boiling point:
- 534.2±50.0 °C(Predicted)
- Density
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble
- pka
- 4.14±0.10(Predicted)
- form
- Off-white solid
N-Bromosuccinimide Price
- Product number
- 440206
- Product name
- LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem<br />A cell-permeable LY 294002 4'-amino derivative with enhanced potency against p110α/β/δ/γ.
- Packaging
- 5mg
- Price
- $251
- Updated
- 2023/01/07
- Product number
- 21811
- Product name
- PI-828
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 21811
- Product name
- PI-828
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 21811
- Product name
- PI-828
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 2814
- Product name
- PI828
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $106
- Updated
- 2021/12/16
PI 828 Chemical Properties,Usage,Production
Definition
ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones.
General Description
A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.
Biological Activity
PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase.
storage
Store at +4°C
PI 828 Preparation Products And Raw materials
Raw materials
Preparation Products
PI 828 Suppliers
- Tel
- 888-539-0666
- Fax
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- Country
- United States
- ProdList
- 8449
- Advantage
- 60
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- Country
- United States
- ProdList
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58