1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- Product Name
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- CAS No.
- 849217-48-7
- Chemical Name
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- Synonyms
- 1-((4-FL;Cabozantinib impurities4;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid
- CBNumber
- CB52460100
- Molecular Formula
- C11H10FNO3
- Formula Weight
- 223.2
- MOL File
- 849217-48-7.mol
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Property
- Melting point:
- 173.0 to 177.0 °C
- Boiling point:
- 475.2±30.0 °C(Predicted)
- Density
- 1.521
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.48±0.20(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
- InChIKey
- PFMAFXYUHZDKPY-UHFFFAOYSA-N
- SMILES
- C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1
Safety
- HS Code
- 2924.29.9500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F1083
- Product name
- 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- F1083
- Product name
- 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $318
- Updated
- 2024/03/01
- Product number
- F632340
- Product name
- 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W8765
- Product name
- 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- W8765
- Product name
- 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid
- Packaging
- 25g
- Price
- $321
- Updated
- 2021/12/16
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White powdery substance.
Uses
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.
Synthesis
Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid manufacturers
- Product
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid 849217-48-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-26
- Product
- CYCLOPROPANECARBOXYLIC ACID 849217-48-7
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-04-28
- Product
- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid 849217-48-7
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000KG/MONTH
- Release date
- 2024-04-17