2-Bromo-5-trifluoromethoxypyridine

Product Name: 2-Bromo-5-trifluoromethoxypyridine
CAS No.: 888327-36-4
Chemical Name: 2-Bromo-5-trifluoromethoxypyridine
Synonyms: Lasmiditan Impurity 41;2-Bromo-5-(trifluoromethoxy);2-Bromo-5-trifluoromethoxypyridine;Pyridine,2-bromo-5-(trifluoromethoxy)-
CBNumber: CB52470062
Molecular Formula: C6H3BrF3NO
Formula Weight: 241.99
MOL File: 888327-36-4.mol

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2-Bromo-5-trifluoromethoxypyridine Property

Boiling point:: 63-66 °C(Press: 11 Torr)
Density: 1.737±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.55±0.10(Predicted)
form: liquid
color: Clear, almost colourless
InChI: InChI=1S/C6H3BrF3NO/c7-5-2-1-4(3-11-5)12-6(8,9)10/h1-3H
InChIKey: RKXYQQVLVNEAFB-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(OC(F)(F)F)C=C1

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Safety

Risk Statements: 43
Safety Statements: 36/37
RIDADR: 2810
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000171
Product name: 2-Bromo-5-(trifluoromethoxy)pyridine
Packaging: 1g
Price: $356
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: HCH0363275
Product name: 2-BROMO-5-(TRIFLUOROMETHOXY)PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $495.54
Updated: 2021/12/16

Apolloscientific

Product number: PC421021
Product name: 2-Bromo-5-(trifluoromethoxy)pyridine
Packaging: 5g
Price: $548
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-9-41
Product name: 2-Bromo-5-(trifluoromethoxy)pyridine
Packaging: 5G
Price: $877
Updated: 2021/12/16

Apolloscientific

Product number: PC421021
Product name: 2-Bromo-5-(trifluoromethoxy)pyridine
Packaging: 500mg
Price: $92
Updated: 2021/12/16

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2-Bromo-5-trifluoromethoxypyridine Chemical Properties,Usage,Production

Synthesis

1206972-45-3

888327-36-4

General procedure for the synthesis of 2-bromo-5-trifluoromethoxypyridine: 2-chloro-5-(trifluoromethoxy)pyridine (6, 7.0 g, 35.4 mmol) and bromotrimethylsilane (10.8 g, 9.3 mL, 70.8 mmol, 2 eq.) were dissolved in propionitrile (35 mL) and heated to reflux for 24 hours. The reaction process was monitored by gas chromatography (GC) to confirm 100% conversion. Upon completion of the reaction, the mixture was vacuum distilled to afford pure 2-bromo-5-trifluoromethoxypyridine (31, 7.0 g, 28.7 mmol, 81% yield) as a colorless oil. Boiling point: 63-66°C (14 mbar). NMR data: 1H NMR (CDCl3, 300 MHz): δ= 8.34 (d, J = 2.8 Hz, 1H), 7.56 (d, J = 8.7 Hz, 1H), 7.45 (dd, J = 8.7, 2.8 Hz, 1H). 19F NMR (CDCl3, 282 MHz): δ= -58.8. 13C NMR (CDCl3, 75 MHz): δ= 145.6, 143.1, 139.2, 131.4, 129.0, 120.1 (q, J = 260 Hz). Elemental analysis: C6H3BrF3NO (molecular weight 241) Calculated value (%): C 29.78, H 1.25, N 5.79; measured value: C 29.96, H 1.41, N 5.64.

References

[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 38-39
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066

2-Bromo-5-trifluoromethoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-trifluoromethoxypyridine Suppliers

China 76 India 2 United Kingdom 1 United States 9 Global 88

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View Lastest Price from 2-Bromo-5-trifluoromethoxypyridine manufacturers

Career Henan Chemical Co

Product: 2-Bromo-5-trifluoromethoxypyridine 888327-36-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-14

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Lasmiditan Impurity 41

888327-36-4

80497-1