(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
- Product Name
- (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
- CAS No.
- 172015-79-1
- Chemical Name
- (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
- Synonyms
- Abaca-2 Impurity;Abacavir Related CoMpound C;Racemization of cloabacavir;( Abacavir USP Related Compound C);Abacavir Related Compound C as Hydrochloride;Abacavir USP Related Compound C as Hydrochloride;Abacavir Impurity 8( Abacavir USP Related Compound C);(1S,4R)-4-(2-Amino-6-chloro-9H-purin-yl)-2-cyclopentene-1-me...;(1S,4R)-4-(2-AMino-6-chloro-9H-purin-yl)-2-cyclopentene-1-Methanol,HCl;[(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol
- CBNumber
- CB52470794
- Molecular Formula
- C11H12ClN5O.ClH
- Formula Weight
- 302.164
- MOL File
- 172015-79-1.mol
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Property
- Melting point:
- 165-170?C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- color
- Off-White to Beige to Brown
Safety
- HS Code
- 2933599550
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- PHR2066
- Product name
- Abacavir Related Compound C
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50mg
- Price
- $712
- Updated
- 2025/07/31
- Product number
- 1000452
- Product name
- Abacavir Related Compound C
- Packaging
- 20mg
- Price
- $825
- Updated
- 2025/07/31
- Product number
- A603506
- Product name
- (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanolHydrochloride
- Packaging
- 10g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- A603506
- Product name
- (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanolHydrochloride
- Packaging
- 25g
- Price
- $1760
- Updated
- 2021/12/16
- Product number
- NA17659
- Product name
- (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol HCl
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White to Tan Solid
Uses
Abacavir intermediate.
Synthesis
171887-04-0
172015-79-1
The general procedure for the synthesis of ((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride from abacavir intermediate A4 was as follows: to the reactor was added N-[2-amino-4-chloro-6-[[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-pyrimidinyl] Formamide (0.1762 mol) and trichloromethylsilicate (7 vol). The reaction mixture was cooled to 0-5 °C and hydrochloric acid (0.7 vol) was added slowly at 0-10 °C. After addition, the reaction was held at 0-5 °C for 60 min. Subsequently, the reaction mixture was brought to room temperature and stirring was continued for 16-18 hours. Upon completion of the reaction, the solid product was collected by filtration and purified by recrystallization in methanol. (Yield: 76%, HPLC purity: 98.69%).
References
[1] Nucleosides, Nucleotides and Nucleic Acids, 2000, vol. 19, # 1-2, p. 297 - 327
[2] Patent: US2017/233329, 2017, A1. Location in patent: Paragraph 0054; 0055
[3] Patent: CN107641122, 2018, A. Location in patent: Paragraph 0016; 0049; 0055-0056; 0059-0073; 0076
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 21-33738120 15000110506
- Fax
- 021-23025272
- info@bioman.com.cn
- Country
- China
- ProdList
- 61
- Advantage
- 62
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
View Lastest Price from (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride manufacturers
- Product
- (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride 172015-79-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-19