ChemicalBook > CAS DataBase List > Abacavir
Abacavir
- Product Name
- Abacavir
- CAS No.
- 783292-37-5
- Chemical Name
- Abacavir
- Synonyms
- Trans -Abacavir;(Abacavir EP Impurity D);Abacavir Impurity 4(Abacavir EP Impurity D);[(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol;2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R,4R)-rel-;(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol
- CBNumber
- CB44656074
- Molecular Formula
- C14H18N6O
- Formula Weight
- 286.33
- MOL File
- 783292-37-5.mol
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Abacavir Property
- Boiling point:
- 636.0±65.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- pka
- 14.86±0.10(Predicted)
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Abacavir Chemical Properties,Usage,Production
Uses
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Abacavir Preparation Products And Raw materials
Raw materials
Preparation Products
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783292-37-5, AbacavirRelated Search:
Lamivudine
Abacavir Carboxylate
Abacavir-d4
Abacavir
Abacavir 5’-Phosphate
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
trans-Abacavir Hydrochloride
Abacavir
2,6-Diaminopurine
6-aminocarbovir
(1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
Abacavir Related CoMpound D
Abacavir
2-Amino-6-cyclopropylamino-9H-purine
Abacavir sulfate