Methyl 3-bromo-4-hydroxybenzoate

Product Name: Methyl 3-bromo-4-hydroxybenzoate
CAS No.: 29415-97-2
Chemical Name: Methyl 3-bromo-4-hydroxybenzoate
Synonyms: EOS-61539;Methyl 3-bromo;Methyl 3-bromo-4-hydroxybenzoa;Methyl3-bromo-4-hydroxybenzoate,98%;Methyl 3-bromo-4-hydroxybenzoayl)carbaMate;Benzoic acid, 3-bromo-4-hydroxy-, methyl ester
CBNumber: CB52488278
Molecular Formula: C8H7BrO3
Formula Weight: 231.04
MOL File: 29415-97-2.mol

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Methyl 3-bromo-4-hydroxybenzoate Property

Melting point:: 108-110℃
Boiling point:: 283.1±20.0 °C(Predicted)
Density: 1.627±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
pka: 6.82±0.18(Predicted)
form: solid
color: White
InChI: InChI=1S/C8H7BrO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3
InChIKey: RKUNSPWAQIUGEZ-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(O)C(Br)=C1

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Safety

RIDADR: UN2811
WGK Germany: WGK 3
HS Code: 2918290090
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Usbiological

Product number: 455177
Product name: Methyl 3-bromo-4-hydroxybenzoate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

TRC

Product number: M296110
Product name: Methyl3-bromo-4-hydroxybenzoate
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: M296110
Product name: Methyl3-bromo-4-hydroxybenzoate
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 024178
Product name: Methyl 3-bromo-4-hydroxybenzoate
Packaging: 25g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR908176
Product name: Methyl3-bromo-4-hydroxybenzoate
Purity: 98%
Packaging: 25g
Price: $67
Updated: 2021/12/16

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Methyl 3-bromo-4-hydroxybenzoate Chemical Properties,Usage,Production

Uses

A reactant used in the preparation of selective inhibitors. In unsymmetrical Ullman reaction between methyl 5bromovanillate (II) and methyl 3-bromo-4-hydroxybenzoate (III) yielded all the three possible dicarbomethoxy-dibenzo-pdioxms which were separated by repeated chromatography over silica gel. A phosphorus- and bromine-containing bifunctional monomer has been prepared from bis(chloromethyl)methylphosphine oxide and the sodium salt of methyl 3-bromo-4-hydroxybenzoate.

Synthesis

67-56-1

14348-41-5

29415-97-2

The general procedure for the synthesis of methyl 3-bromo-4-hydroxybenzoate from methanol and 3-bromo-4-hydroxybenzoic acid is as follows: 1. Preparation of intermediate T3.1 (methyl 3-bromo-4-hydroxybenzoate): - Under stirring conditions, 3-bromo-4-hydroxybenzoic acid (50.0 g, 231 mmol) was dissolved in methanol (300 mL). - To the above solution was slowly added cold sulfuric acid solution (2.50 mL, 47 mmol). - The reaction mixture was heated to 80 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). - After 16.5 h of reaction, the solvent was removed by distillation under reduced pressure. - The reaction mixture was diluted with ethyl acetate (EtOAc). - The organic phase was sequentially washed twice with saturated aqueous sodium bicarbonate (NaHCO3), once with brine and then dried with anhydrous sodium sulfate. - After filtration, the organic solvent was removed by distillation under reduced pressure to give the intermediate T3.1 as a white solid in 100% yield, which can be used in the next reaction without further purification.

References

[1] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 119
[2] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 103; 141
[3] Patent: WO2017/36404, 2017, A1. Location in patent: Paragraph 57; 58
[4] Patent: EP2380890, 2011, A1. Location in patent: Page/Page column 35
[5] Macromolecules, 2003, vol. 36, # 12, p. 4328 - 4336

Methyl 3-bromo-4-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-bromo-4-hydroxybenzoate Suppliers

China 142 Germany 3 India 16 Russia 1 Switzerland 1 The Netherlands 1 United Kingdom 1 United States 10 Global 175

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View Lastest Price from Methyl 3-bromo-4-hydroxybenzoate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 3-bromo-4-hydroxybenzoa 29415-97-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-05-08

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 3-bromo-4-hydroxybenzoa 29415-97-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-04-02

Zibo Shiji Zhonglian Medical Technology Co., Ltd.

Product: Methyl 3-bromo-4-hydroxybenzoate 29415-97-2
Price: US $1.00-1.00/KG
Min. Order: 25KG
Purity: 99.0%
Supply Ability: 3000KG/th
Release date: 2023-06-13

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Methyl 3-bromo-4-hydroxybenzoa

EOS-61539

Benzoic acid, 3-bromo-4-hydroxy-, methyl ester

Methyl3-bromo-4-hydroxybenzoate,98%

Methyl 3-bromo-4-hydroxybenzoayl)carbaMate

Methyl 3-bromo

29415-97-2