Aflibercept

Product Name: Aflibercept
CAS No.: 862111-32-8
Chemical Name: Aflibercept
Synonyms: VEGF trap;Aflibercept1;VEGF Trap R1R2;Research Grade Aflibercept;Aflibercept iso-osmotic ophthalmic;Research Grade Aflibercept(DHD12629)
CBNumber: CB52498796
Molecular Formula: C4318H6788N1164O1304S32
Formula Weight: 0
MOL File: Mol file

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Aflibercept Property

form: Liquid
color: Colorless to light yellow

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Safety

Hazardous Substances Data: 862111-32-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BA165580
Product name: Aflibercept
Packaging: 1mg
Price: $600
Updated: 2021/12/16

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Aflibercept Chemical Properties,Usage,Production

Description

In November 2011, the U.S. FDA approved the recombinant fusion protein aflibercept, administered as an intravitreal injection, for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD). Aflibercept differs from these agents in that it acts as a soluble decoy receptor that binds all VEGF isoforms more tightly than their native receptors, thereby diverting VEGF from its normal function. Aflibercept consists of a fusion of the second Ig domain of human VEGF receptor 1 and the third Ig domain of human VEGF receptor 2 fused to the constant region of (Fc) of human immunoglobulin G1. Aflibercept is a dimeric glycoprotein with a protein molecular weight of 97 kDa and glycoside molecular weight of 18 kDa. It is produced in recombinant Chinese hamster ovary (CHO) cells that overexpress the fusion protein. Aflibercept has subpicomolar affinity for VEGF-A (K_D=0.66 pM for VEGF-A₁₆₅ and 0.19 pM for VEGF-A₁₂₁), the major driver of pathological angiogenesis and vascular leak in wet AMD.19 Ranibizumab and bevacizumab bind VEGF-A₁₆₅ with lower affinity (K_D=20.6 and 35.1 pM, respectively).

Originator

Regeneron Pharmaceuticals (United States)

brand name

Eylea

Aflibercept Preparation Products And Raw materials

Raw materials

Preparation Products

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Aflibercept Suppliers

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862111-32-8, AfliberceptRelated Search:

Follicle stimulating hormone Secukinumab Daratumumab OMALIZUMAB Dulaglutide Trastuzumab emtansine Ranibizumab palivizumab Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer Eculizumab Matuzumab ticilimumab tremelimumab CNTO 148 abciximab Vedolizumab Avelumab nimotuzumab belimumab

Aflibercept iso-osmotic ophthalmic

VEGF trap

VEGF Trap R1R2

Research Grade Aflibercept(DHD12629)

Aflibercept1

Research Grade Aflibercept

862111-32-8

C4318H6788N1164O1304S32