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Aflibercept

Product Name
Aflibercept
CAS No.
862111-32-8
Chemical Name
Aflibercept
Synonyms
VEGF trap;Aflibercept1;VEGF Trap R1R2;Research Grade Aflibercept;Aflibercept iso-osmotic ophthalmic;Research Grade Aflibercept(DHD12629)
CBNumber
CB52498796
Molecular Formula
C4318H6788N1164O1304S32
Formula Weight
0
MOL File
Mol file
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Aflibercept Property

form 
Liquid
color 
Colorless to light yellow
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Safety

Hazardous Substances Data
862111-32-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BA165580
Product name
Aflibercept
Packaging
1mg
Price
$600
Updated
2021/12/16
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Aflibercept Chemical Properties,Usage,Production

Description

In November 2011, the U.S. FDA approved the recombinant fusion protein aflibercept, administered as an intravitreal injection, for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD). Aflibercept differs from these agents in that it acts as a soluble decoy receptor that binds all VEGF isoforms more tightly than their native receptors, thereby diverting VEGF from its normal function. Aflibercept consists of a fusion of the second Ig domain of human VEGF receptor 1 and the third Ig domain of human VEGF receptor 2 fused to the constant region of (Fc) of human immunoglobulin G1. Aflibercept is a dimeric glycoprotein with a protein molecular weight of 97 kDa and glycoside molecular weight of 18 kDa. It is produced in recombinant Chinese hamster ovary (CHO) cells that overexpress the fusion protein. Aflibercept has subpicomolar affinity for VEGF-A (KD=0.66 pM for VEGF-A165 and 0.19 pM for VEGF-A121), the major driver of pathological angiogenesis and vascular leak in wet AMD.19 Ranibizumab and bevacizumab bind VEGF-A165 with lower affinity (KD=20.6 and 35.1 pM, respectively).

Originator

Regeneron Pharmaceuticals (United States)

brand name

Eylea

Aflibercept Preparation Products And Raw materials

Raw materials

Preparation Products

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