CP-724714

Product Name: CP-724714
CAS No.: 537705-08-1
Chemical Name: CP-724714
Synonyms: CS-521;CS-2401;CP-724714;(E/Z)-CP-724714;CP-724714 CP724714;CP-724714 USP/EP/BP;-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl);2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba
CBNumber: CB52501007
Molecular Formula: C27H27N5O3
Formula Weight: 469.54
MOL File: 537705-08-1.mol

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CP-724714 Property

solubility: ≥23.5 mg/mL in DMSO; insoluble in H2O; ≥25.4 mg/mL in EtOH
form: solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A2412
Product name: CP-724714
Packaging: 5mg
Price: $85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0392155
Product name: (E)-ETHYL-(3-(4-((3-METHYL-4-((6-METHYLPYRIDIN-3-YL)OXY)PHENYL)AMINO)QUINAZOLIN-6-YL)ALLYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $499.15
Updated: 2021/12/16

AK Scientific

Product number: X7480
Product name: (E)-Ethyl(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate
Packaging: 25mg
Price: $540
Updated: 2021/12/16

Chemenu

Product number: CM133309
Product name: ethyl(E)-(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate
Purity: 95%
Packaging: 5g
Price: $795
Updated: 2021/12/16

DC Chemicals

Product number: DC8892
Product name: CP724714
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

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CP-724714 Chemical Properties,Usage,Production

Uses

CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.

Biological Activity

cp-724714 is an inhibitor of erbb2 and egfr kinases with ic50 values of 10±3 nmol/l and 6,400±2,100 nmol/l, respectively [1].in the in vitro cell cycle assay, cp-724714 cause a g1 block of the her2-amplified bt-474 breast cancer cells due to its inhibition of erbb2. cp-724714 at 1 mol/l can also reduce the level of phospho-erbb2 in these cells. in in vivo assay, cp-724714 cause a concentration-dependent reduction of tumor erbb2 receptor phosphorylation in athymic mice bearing fre-erbb2xenografts. cp-724714 treatments also resulted in a time- and dose-dependent induction of tumor cell apoptosis. in two human breast carcinoma models, bt-474 and mda-mb-453, which are her2 amplified and highly overexpress erbb2, cp-724714 is found to produce a dose-dependent inhibition of xenograft growth. in addition, cp-724,714 treatments induce reduction of downstream erbb2 rtk signaling. on the basis of these, cp-724,714 was advanced to phase i clinical trials and is potentially another option for her2-driven breast cancer [1].

target

erbB2

References

[1] jitesh p. jani, richard s. finn, mary campbell, et al. discovery and pharmacologic characterization of cp-724714, a selective erbb2 tyrosine kinase inhibitor. cancer research. 2007 (67): 9887-9893.

CP-724714 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-724714 Suppliers

China 84 India 1 United States 16 USA 1 Global 102

MedChemexpress LLC

Tel: 021-58955995
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AdooQ BioScience, LLC

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Target molecule Corp.

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InvivoChem

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Cckinase, Inc.

Tel: +1 (732)236-3202
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Alchem Pharmtech,Inc.

Tel: 8485655694
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TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
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Aladdin Scientific

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United States Biological

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ApexBio Technology

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Santa Cruz Biotechnology, Inc.

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Selleck Chemicals LLC

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United States Biological

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Creative Enzymes

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MedChemExpress

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Matrix Scientific

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View Lastest Price from CP-724714 manufacturers

Career Henan Chemical Co

Product: CP-724714 537705-08-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

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(E)-Ethyl (3-(4-((3-Methyl-4-((6-Methylpyridin-3-yl)oxy)phenyl)aMino)quinazolin-6-yl)allyl)carbaMate

acetaMide, 2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methyl-3-pyridinyl)oxy]phenyl]aMino]-6-quinazolinyl]-2-propen-1-yl]-

(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba

CP-724714

2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide

(E)-2-Methoxy-N-(3-(4-(3-Methyl-4-(6-Methylpyridin-3-yloxy)phenylaMino)quinazolin-6-yl)allyl)acetaMide

-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)

(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca

CS-2401

CS-521

2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]acetamide

CP-724714 USP/EP/BP

(E/Z)-CP-724714

2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester

CP-724714 CP724714

537705-08-1

Inhibitors