Oxiconazole nitrate

Product Name: Oxiconazole nitrate
CAS No.: 64211-46-7
Chemical Name: Oxiconazole nitrate
Synonyms: Oceral;Oxistat;Myfungar;Okiconale;Sgd-301-76;Ro-13-8996;Okiconale V;Gyno-Myfungar;Oxiconazole nitrate;nitrate,(z)-methyl)oxim
CBNumber: CB5251601
Molecular Formula: C18H13Cl4N3O
Formula Weight: 429.13
MOL File: 64211-46-7.mol

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Oxiconazole nitrate Property

Melting point:: 137-1380C
storage temp.: Refrigerator
solubility: Chloroform, Methanol (Sparingly)
form: Solid
color: Off-White
CAS DataBase Reference: 64211-46-7(CAS DataBase Reference)

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Safety

HS Code: 2933290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18724
Product name: Oxiconazole (nitrate)
Purity: ≥98%
Packaging: 1g
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 18724
Product name: Oxiconazole (nitrate)
Purity: ≥98%
Packaging: 5g
Price: $347
Updated: 2024/03/01

Cayman Chemical

Product number: 18724
Product name: Oxiconazole (nitrate)
Purity: ≥98%
Packaging: 25g
Price: $1153
Updated: 2024/03/01

TRC

Product number: O846800
Product name: OxiconazoleNitrate
Packaging: 100mg
Price: $1070
Updated: 2021/12/16

Usbiological

Product number: 286092
Product name: Oxiconazole nitrate
Packaging: 5mg
Price: $403
Updated: 2021/12/16

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Oxiconazole nitrate Chemical Properties,Usage,Production

Description

Oxiconazole nitrate is a broad-spectrum antifungal agent indicated for the treatment of skin infections due to yeasts, dermatophytes, yeast-like fungi and molds, and gram positive organisms.

Description

Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes. Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.

Chemical Properties

Crystalline Solid

Originator

Siegfried (Switzerland)

Uses

Topical aTopical antimycotic agent. agent.

Uses

radiopaque agent

Definition

ChEBI: An organic nitrate salt resulting from the reaction of equimolar amounts of oxiconazole and nitric acid. An antifungal agent, it is used in creams and powders for the topical treatment of fungal skin infections.

Manufacturing Process

13.5 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime are dissolved in 100 ml dimethylformamide (DMF) and 1.2 g of sodium hydride are mixed in, whereupon an exothermic reaction is allowed to take place on its own with stirring. After cessation of evolution of hydrogen, a solution of 9.8 g of 2,4-dichlorobenzyl chloride in 10 cc DMF is added dropwise with continuous stirring and the stirring is carried on for 2 hours further. The reaction is then taken to completion at a bath temperature of 80°C, after which the reaction mixture is evaporated in a rotation evaporator under reduced pressure and the residue is dissolved in 100 ml ethanol. After filtering off of undissolved matter, the solution is stirred with 300 ml 2N nitric acid for the conversion of free base to the nitrate.
The liquid standing over the heavy deposits which have separated out is separated off by decanting, whereupon an isomer is obtained which after recrystallization from ethanol is obtained in a yield of 5.2 g and having a melting point of 137°C to 138°C.

brand name

Oxistat (Altana);OCERAL;MYFUNGAR.

Therapeutic Function

Antifungal

Clinical Use

(Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone-O-[2,4-dichlorophenyl)methyl]oxime mononitrate (Oxistat)is a white crystalline nitric acid salt. It is used in cream andlotion dosage forms in 1% concentration for the treatment oftinea pedis, tinea corporis, and tinea capitis.

in vitro

oxiconazole is highly effective against many dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton tonsurans, and epidermophyton floccosum. after application to the skin, oxiconazole is rapidly absorbed into the stratum corneum, maximum concentrations often being attained within 100 minutes. fungicidal concentrations are maintained in the epidermis, upper corium, and deeper corium for at least five hours, and levels exceeding the minimum inhibitory concentrations of susceptible fungi are present in the corneum, epidermis, upper corium, and the hair follicle for over 16 hours [2].

References

[1] polak a. oxiconazole, a new imidazole derivative. evaluation of antifungal activity in vitro and in vivo[j]. arzneimittel-forschung, 1981, 32(1): 17-24.
[2] jegasothy b v, pakes g e. oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent[j]. clinical therapeutics, 1990, 13(1): 126-141.

Oxiconazole nitrate Preparation Products And Raw materials

Raw materials

Ethylene glycol methyl ether Ketone oxime Imidazole Hydroxylamine hydrochloride 2,2',4'-Trichloroacetophenone 2,4-Dichlorobenzoyl chloride

Preparation Products

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Oxiconazole nitrate Suppliers

Canada 1 China 131 Europe 3 Germany 1 India 13 South Korea 1 United Kingdom 5 United States 19 Global 174

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View Lastest Price from Oxiconazole nitrate manufacturers

Dideu Industries Group Limited

Product: Oxiconazole nitrate 64211-46-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Oxiconazole nitrate 64211-46-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Oxiconazole nitrate 64211-46-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

64211-46-7, Oxiconazole nitrateRelated Search:

Acetophenone Econazole nitrate Ethyl acrylate 4'-Hydroxyacetophenone 2'-Hydroxyacetophenone Ethyl vanillin 3-Nitroacetophenone 3-Aminoacetophenone Ethyl 4-hydroxy-3-methoxycinnamate 4-Nitroacetophenone Ethylparaben NITRATE Dichloroacetonitrile 2-Bromoacetophenone 2',4'-Dichloroacetophenone Miconazole nitrate Ethanol Oxiconazole

(Z)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[(2,4-Dichlorophenyl)methyl]oxime Mononitrate

Myfungar

Oceral

Oxistat

Ro-13-8996

Sgd-301-76

Oxiconazole nitrate

(Z)-1-(2，4-Diehlorophenyl)-2-(1H-imidazol-1-y1)ethanone O-[(2，4-diehlorophenyl)methyl]oxime mononitrate

Gyno-Myfungar

(Z)-1-(2,4-Dichlorophenyl)-2-(1H-iMidazol-1-yl)ethanone O-(2,4-dichlorobenzyl) oxiMe nitrate

2’,4’-dichloro-2-imidazol-1-ylacetophenone(z)-(o-(2,4-dichlorobenzyl))oxime

ethanone,1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)-,o-((2,4-dichlorophenyl)

nitrate,(z)-methyl)oxim

(Z)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone

2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(o-(2,4-dichlorobenzyl))oxime nitrate

Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, o-((2,4-dichlorophenyl)methyl)oxime, nitrate, (Z)-

O-[(2,4-Dichlorophenyl)methyl]oxime, (Z)-, mononitrate

Okiconale

Okiconale V

(E)-[1-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-yl)ethylidene][(2,4-dichlorophenyl)Methoxy]aMine

Oxiconazole nitrate (Oxistat)

(Z)-1-[2-(2,4-dichlorophenyl)-2-[[(2,4-dichlorophenyl)oxy]imino]ethyl]-1H-imidazole mononitrate

N-(2,4-dichlorophenoxy)-1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanimine

Oxiconazole nitrate USP/EP/BP

Oxiconazole NitrateQ: What is Oxiconazole Nitrate Q: What is the CAS Number of Oxiconazole Nitrate Q: What is the storage condition of Oxiconazole Nitrate Q: What are the applications of Oxiconazole Nitrate

Oxiconazole nitrate API

Oxiconazole Nitrate (1483425)

Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-,O-[(2,4-dichlorophenyl)methyl]oxime, (1Z)-, mononitrate

64211-46-7

C18H14Cl4N4O4

C18H13Cl4N3OHNO3

C17H12Cl4N4O4

49214

API

OXILAN

Intermediates & Fine Chemicals

Pharmaceuticals

Oxiconazole