ChemicalBook > CAS DataBase List > 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Product Name
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
CAS No.
1124329-14-1
Chemical Name
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Synonyms
CS-511;AZ 3146;AZ 3146; AZ-3146;AZ3146 >=98% (HPLC);AZ3146, 10 mM in DMSO;AZ3146; AZ 3146; AZ-3146;AZ3146 Mps1 Inhibitor III AZ-3146;9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one
CBNumber
CB52518786
Molecular Formula
C24H32N6O3
Formula Weight
452.55
MOL File
1124329-14-1.mol
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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Property

Boiling point:
621.0±65.0 °C(Predicted)
Density 
1.279
storage temp. 
Store at +4°C
solubility 
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form 
solid
pka
8.29±0.10(Predicted)
color 
Off-white
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19991
Product name
AZ 3146
Purity
≥98%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
19991
Product name
AZ 3146
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
19991
Product name
AZ 3146
Purity
≥98%
Packaging
25mg
Price
$414
Updated
2024/03/01
Cayman Chemical
Product number
19991
Product name
AZ 3146
Purity
≥98%
Packaging
50mg
Price
$547
Updated
2024/03/01
Tocris
Product number
3994
Product name
AZ3146
Purity
≥99%(HPLC)
Packaging
50
Price
$1040
Updated
2021/12/16
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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties,Usage,Production

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

Uses

AZ 3146 is a protein kinase Mps1 inhibitor.

storage

Store at +4°C

References

1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Suppliers

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1124329-14-1, 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-oneRelated Search:

NOTUMib-1 Elafibranor(GFT505) Acalabrutinib NORFLUOXETINE HYDROCHLORIDE MK-1775 ABT-199 MPI-0479605 PF-4708671 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide Fedratinib

  • AZ 3146; AZ-3146
  • CS-511
  • 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
  • AZ 3146
  • 9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one
  • 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one
  • 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146
  • 9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9
  • AZ3146; AZ 3146; AZ-3146
  • 8H-Purin-8-one, 9-cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-
  • AZ3146 >=98% (HPLC)
  • 9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one
  • 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one USP/EP/BP
  • AZ3146 Mps1 Inhibitor III AZ-3146
  • AZ3146, 10 mM in DMSO
  • 1124329-14-1
  • Inhibitors