Chonglou Saponin VII

Product Name: Chonglou Saponin VII
CAS No.: 68124-04-9
Chemical Name: Chonglou Saponin VII
Synonyms: Paris VII;Dioscinin;Paris VII-RM;Chonglouoside Ⅶ;Polyphyllin VIT;Chonglouoside Ⅶ;Chonglou SaponinG;Paris saponin VII;Chonglou saponin Ⅶ;Chonglou Saponin VII
CBNumber: CB52519622
Molecular Formula: C51H82O21
Formula Weight: 1031.2
MOL File: 68124-04-9.mol

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Chonglou Saponin VII Property

Melting point:: 243-245 °C (decomp)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: Soluble in methanol;
pka: 12?+-.0.70(Predicted)
form: powder
color: White
Water Solubility: sparingly soluble in water

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Safety

HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0023885
Product name: ParissaponinVII
Purity: 99.13%
Packaging: 5mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-0023885
Product name: ParissaponinVII
Purity: 99.13%
Packaging: 10mg
Price: $230
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0005387
Product name: CHONGLOU SAPONIN VII
Purity: 95.00%
Packaging: 5MG
Price: $459.96
Updated: 2021/12/16

Biosynth Carbosynth

Product number: OC42613
Product name: Chonglou Saponin VII
Packaging: 10mg
Price: $800
Updated: 2021/12/16

AK Scientific

Product number: W2311
Product name: ChonglouSaponinVII
Packaging: 10mg
Price: $1130
Updated: 2021/12/16

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Chonglou Saponin VII Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Used for content determination/identification/pharmacological experiments, etc.

Biological Activity

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.

Pharmacology

Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.

in vitro

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.

in vivo

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

target

Akt

p38

Bcl-2

Caspase-9

Caspase-3

PARP-1

Chonglou Saponin VII Preparation Products And Raw materials

Raw materials

Preparation Products

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Chonglou Saponin VII Suppliers

China 97 India 1 United States 9 Global 107

Chembest Research Laboratories Limited

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Chengdu Biopurify Phytochemicals Ltd.

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Shanghai CanSpecsci Instrument Co., Ltd.

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ALB Technology Limited

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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View Lastest Price from Chonglou Saponin VII manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Chonglou Saponin VII 68124-04-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-28

Career Henan Chemical Co

Product: Chonglou Saponin VII 68124-04-9
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

68124-04-9, Chonglou Saponin VIIRelated Search:

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Chonglou Saponin VII

Paris VII

Chonglouoside Ⅶ

Paris saponin VII

Dioscinin

Chonglou saponin Ⅶ

β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-

Polyphyllin VIT

Chonglouoside Ⅶ

Chonglou SaponinG

Paris VII-RM

68124-04-9