p-Coumaric acid ethyl ester
- Product Name
- p-Coumaric acid ethyl ester
- CAS No.
- 7362-39-2
- Chemical Name
- p-Coumaric acid ethyl ester
- Synonyms
- p-Coumaric acid ethyl ester;Ethyl (E)-p-hydroxycinnamate;Ethyl trans-4-hydroxycinnamate;(E)-Ethyl 3-(4-hydroxyphenyl)acrylate;trans-p-Hydroxycinnamic acid ethyl ester;p-Coumaric Acid Ethyl Ester, 10 mM in DMSO;2-Propenoic acid, 3-(4-hydroxyphenyl)-, ethyl ester, (2E)-;pCoumaric Acid Ethyl Ester,Drug Metabolite,TNF-α,p-Coumaric Acid Ethyl Ester,Inhibitor,inhibit,immunomodulatory,autoimmune,p Coumaric Acid Ethyl Ester
- CBNumber
- CB52519925
- Molecular Formula
- C11H12O3
- Formula Weight
- 192.21
- MOL File
- 7362-39-2.mol
p-Coumaric acid ethyl ester Property
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- Light yellow to light brown
Safety
- HS Code
- 2918290090
N-Bromosuccinimide Price
- Product number
- E945825
- Product name
- (E)-Ethyl3-(4-hydroxyphenyl)acrylate
- Packaging
- 20mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A104956
- Product name
- p-CoumaricAcidEthylEster
- Purity
- 98%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- 7362392
- Product name
- p-CoumaricAcidEthylEster
- Packaging
- 5g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- CD32000514
- Product name
- p-CoumaricAcidEthylEster
- Purity
- 97%
- Packaging
- 10g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- A104956
- Product name
- p-CoumaricAcidEthylEster
- Purity
- 98%
- Packaging
- 5g
- Price
- $313
- Updated
- 2021/12/16
p-Coumaric acid ethyl ester Chemical Properties,Usage,Production
Uses
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid[1]. p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis[1].
Definition
ChEBI: Ethyl p-coumarate is a cinnamate ester.
Synthesis
540-38-5
140-88-5
2979-06-8
The general procedure for the synthesis of ethyl 3-(4-hydroxyphenyl)acrylate from 4-iodophenol and ethyl acrylate was carried out as follows: a mixture of 4-iodophenol (5 g, 22.93 mmol), ethyl acrylate (4.587 g, 45.87 mmol), and potassium carbonate (6.330 g, 45.87 mmol) was dissolved in DMF (15 ml), followed by addition of SS- Pd catalyst (10.27 g, 2 mol% Pd). The reaction mixture was heated and stirred at 100 °C for 6 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with ethyl acetate (15 ml) and washed with cold water. The organic layer was further washed with brine and dried over anhydrous Na2SO4. The crude product was purified by column chromatography (eluent: EtOAc/hexane, 1:99) to afford ethyl (E)-3-(4-hydroxyphenyl)acrylate as a colorless liquid (4.051 g, 93% yield).
target
Carbonic Anhydrase
References
[1] T. Silva, et al. Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors. RSC Advances. Issue 72, 2015.
[2] Pragasam SJ,?et al. Immunomodulatory and anti-inflammatory effect of?p-coumaric acid, a common dietary polyphenol on experimental inflammation in rats. Inflammation.?2013 Feb;36(1):169-76. DOI:10.1007/s10753-012-9532-8
p-Coumaric acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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