ChemicalBook > CAS DataBase List > 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

Product Name: 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
CAS No.: 908112-43-6
Chemical Name: 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
Synonyms: CS-345;SNX-2112;PF 04928473;SNX-2112 (PF-04928473);SNX2112, 10 mM in DMSO;PF-04928473;PF 04928473;SNX-2112 PF-04928473 SNX2112;SNX-2112 (PF-04928473) ，S2639;4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hyd;4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
CBNumber: CB52521063
Molecular Formula: C23H27F3N4O3
Formula Weight: 464.48
MOL File: 908112-43-6.mol

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4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide Property

Melting point:: 265-266℃
Boiling point:: 619.8±55.0 °C(Predicted)
Density: 1.47
storage temp.: Store at -20°C
solubility: ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥9.6 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 15.07±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22359
Product name: SNX-2112
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22359
Product name: SNX-2112
Purity: ≥98%
Packaging: 5mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 22359
Product name: SNX-2112
Purity: ≥98%
Packaging: 10mg
Price: $401
Updated: 2024/03/01

Cayman Chemical

Product number: 22359
Product name: SNX-2112
Purity: ≥98%
Packaging: 25mg
Price: $917
Updated: 2024/03/01

Usbiological

Product number: 474190
Product name: SNX 2112
Packaging: 100mg
Price: $1805
Updated: 2021/12/16

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4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide Chemical Properties,Usage,Production

Uses

SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis in a mechanism dependent on the degredation of Hsp90 client proteins.

target

Hsp90α

IC 50

HSP90α: 30 nM (IC₅₀); HSP90β: 30 nM (IC₅₀); GRP94: 4275 nM (IC₅₀); TRAP-1: 862 nM (IC₅₀)

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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908112-43-6, 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamideRelated Search:

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea 1 NM-PP1 BLU 9931 ZLN005 Esomeprazole magnesium Tariquidar Palbociclib IXABEPILONE L-4-THIAZOLYLALANINE Ilomastat AZD-1208 Crenolanib Doxorubicin hydrochloride BIIB-021 PF-04929113 PU-H71 17-DMAG Onalespib

PF 04928473

SNX-2112 (PF-04928473)

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hyd

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

SNX-2112

SNX-2112;4-(6,6-DIMETHYL-4-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)-2-((1R,4R)-4-HYDROXYCYCLOHEXYLAMINO)BENZAMIDE

2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide

PF-04928473;PF 04928473

CS-345

Benzamide, 2-[(trans-4-hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]-

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide USP/EP/BP

4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((trans-4-hydroxycyclohexyl)amino)benzamide

SNX-2112 PF-04928473 SNX2112

4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((trans-4-hydroxycyclohexyl)amino)benzamide , SNX-2112

SNX2112, 10 mM in DMSO

SNX-2112 (PF-04928473) ，S2639

908112-43-6

C23H27F3N4O3

Inhibitors

Inhibitor