Indications and Usage Mechanisms of Action Contraindications Category Toxicity level Acute toxicity Flammability Storage and transport Extinguishing agents
ChemicalBook > CAS DataBase List > Betamethasone 21-phosphate disodium

Betamethasone 21-phosphate disodium

Indications and Usage Mechanisms of Action Contraindications Category Toxicity level Acute toxicity Flammability Storage and transport Extinguishing agents
Product Name
Betamethasone 21-phosphate disodium
CAS No.
151-73-5
Chemical Name
Betamethasone 21-phosphate disodium
Synonyms
BETAMETHASONE SODIUM PHOSPHATE;BETAMETHASONE 21-DISODIUM PHOSPHATE;Durabetason;betnesol;bentelan;Celestan;Bentalan;NSC 90616;Vista-Methasone;Betamethasone 21-pho
CBNumber
CB5252688
Molecular Formula
C22H28FNa2O8P
Formula Weight
516.4
MOL File
151-73-5.mol
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Betamethasone 21-phosphate disodium Property

Melting point:
206-211°C
alpha 
+98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
storage temp. 
room temp
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form 
Solid
color 
White to Off-White
PH
7.5～9.0(5g/l, 25℃)
Merck 
14,1180
Stability:
Hygroscopic
InChIKey
PLCQGRYPOISRTQ-LWCNAHDDSA-L
SMILES
[C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r|
EPA Substance Registry System
.beta.-Methasone disodium phosphate (151-73-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TU4056500
HS Code 
29372290
Toxicity
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B7652
Product name
Betamethasone 21-phosphate disodium
Purity
≥97%
Packaging
1g
Price
$372
Updated
2024/03/01
Sigma-Aldrich
Product number
1068004
Product name
Betamethasone sodium phosphate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
B4110
Product name
Betamethasone 21-Phosphate Disodium Salt
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
B7652
Product name
Betamethasone 21-phosphate disodium
Purity
≥97%
Packaging
250mg
Price
$62
Updated
2024/03/01
Sigma-Aldrich
Product number
B1045000
Product name
Betamethasone sodium phosphate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
b1045000
Price
$220
Updated
2024/03/01
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Betamethasone 21-phosphate disodium Chemical Properties,Usage,Production

Indications and Usage

Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.

Mechanisms of Action

Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.

Contraindications

Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.

Category

Toxic

Toxicity level

Medium

Acute toxicity

Oral administration - mice LD50: >4500 mg/kg

Flammability

Flammable; produces toxic fluoride fumes

Storage and transport

Store in a cool, ventilated, and dry place

Extinguishing agents

Dry powder, foam, sand, carbon dioxide, mist

Chemical Properties

White or almost white powder, very hygroscopic.

Uses

Nasal, Ophthalmic, Oral, Parenteral

Uses

Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.

Definition

ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

brand name

Celestone (Schering).

Biochem/physiol Actions

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

Safety Profile

Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.

Betamethasone 21-phosphate disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Betamethasone 21-phosphate disodium Suppliers

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View Lastest Price from Betamethasone 21-phosphate disodium manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Betamethasone 21-phosphate disodium/Durabetason 151-73-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
Wuhan Boyuan Import & Export Co., LTD
Product
Betamethasone 21-phosphate disodium salt 151-73-5
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000tons
Release date
2023-08-03
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Betamethasone Sodium Phosphate 151-73-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-22

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