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Betamethasone 21-acetate

Product Name
Betamethasone 21-acetate
CAS No.
987-24-6
Chemical Name
Betamethasone 21-acetate
Synonyms
BETAMETHASONE ACETATE;Betamethasone 21-ace;Betamethasone 21-Acetata;BETAMETHASONE 21-ACETATE;Betamethasone acetate CRS;Betamethasone Acetate API;Betamethasone21-acetatemicro;Betamethasone Acetate (500 mg);BETAMETHASONE ACETATE LINIMENTS;Betamethasone acetate BP/USP/EP
CBNumber
CB1337284
Molecular Formula
C24H31FO6
Formula Weight
434.5
MOL File
987-24-6.mol
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Betamethasone 21-acetate Property

Melting point:
200-220°C (dec.)
alpha 
D +140° (chloroform)
Boiling point:
579.4±50.0 °C(Predicted)
Density 
1.0932 (rough estimate)
refractive index 
1.5980 (estimate)
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka
12.08±0.70(Predicted)
color 
White to Off-White
Water Solubility 
30mg/L(25 ºC)
Merck 
14,1180
CAS DataBase Reference
987-24-6(CAS DataBase Reference)
EPA Substance Registry System
.beta.-Methasone acetate (987-24-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
WGK Germany 
3
HS Code 
2937220000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1779
Product name
Betamethasone acetate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
1067001
Product name
Betamethasone acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
B1030000
Product name
Betamethasone acetate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
b1030000
Price
$220
Updated
2024/03/01
TRC
Product number
B327025
Product name
Betamethasone21-Acetate
Packaging
1g
Price
$1185
Updated
2021/12/16
TRC
Product number
B327025
Product name
Betamethasone21-Acetate
Packaging
5mg
Price
$95
Updated
2021/12/16
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Betamethasone 21-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Celestone Soluspan,Schering,US,1965

Uses

Betamethasone acetate (BA)

Uses

amino acid, nutrient

Uses

CORTICOSTEROID

Definition

ChEBI: Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone.

Manufacturing Process

The synthesis is long and complex. For brevity, only the last steps are given here. Refer to the patents cited below for full details.
Preparation of 9α-Bromo-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a mixture of 620 mg of 17α,21-dihydroxy-16β-methyl- 4,9(11)-pregnadiene-3,20-dione 21-acetate and 330 mg of Nbromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at 15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition of aqueous sodium thiosulfate and most of the dioxane was removed in vacuo. About 30 ml of water was added and crystalline bromohydrin, 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate, was filtered, washed with water, and dried in air. Preparation of 9β,11β-Epoxy-17α-21-Dihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a stirred solution of 100 mg of the 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of 0.215N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of acetic acid was added and the methanol removed in vacuo. The residue was acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for 70 minutes. The mixture was taken to dryness in vacuo, water added, and the product extracted into chloroform. The residue was crystallized from etheracetone to give pure 9β,11β-epoxy-17α,21-dihydroxy-16β-methyl-4-pregnene- 3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a solution of 200 mg of 9β,11β-epoxy-17α,21-dihydroxy- 16β-methyl-4-pregnene-3,20-dione 21-acetate in 2 ml of chloroform and 2 ml of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2:1 (by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After 4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of chloroform kept at -5°C. The aqueous phase was further extracted with chloroform and the latter phase washed with water and dried over magnesium sulfate. The residue on crystallization from acetone-ether gave pure 9α-fluoro- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnadiene- 3,20-Dione 21-Acetate 100 mg of 9α-fluoro-11β,17α,21-trihydroxy-16β- methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide to produce the corresponding 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-4- pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be utilized.

Therapeutic Function

Glucocorticoid

Betamethasone 21-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Betamethasone 21-acetate Suppliers

Shanghai New Hualian Co., Ltd
Tel
021-64403190
Fax
021-64403190*8043
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
Email
shchemsky@sina.com
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China
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32344
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XiaoGan ShenYuan ChemPharm co,ltd
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0712-0712-2580635 15527768850
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1791901229@qq.com
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China
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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86-21-63290778 86-21-63218885
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sj_scrc@sinopharm.com
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China
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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021-57711696
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marketing_china@spectrumchemical.com
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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0755-83725681-603
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+86 755 28094224
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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03-3668-0520
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Sales-JP@TCIchemicals.com
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Japan
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View Lastest Price from Betamethasone 21-acetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Betamethasone 21-acetate/Betamethasone Acetate 987-24-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27
Hebei Fengqiang Trading Co., LTD
Product
Betamethasone 21-acetate 987-24-6
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-09-01
Hebei Mojin Biotechnology Co., Ltd
Product
Betamethasone 21-acetate 987-24-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-11

987-24-6, Betamethasone 21-acetateRelated Search:


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