Betamethasone 21-phosphate disodium
Indications and Usage Mechanisms of Action Contraindications Category Toxicity level Acute toxicity Flammability Storage and transport Extinguishing agents- Product Name
- Betamethasone 21-phosphate disodium
- CAS No.
- 151-73-5
- Chemical Name
- Betamethasone 21-phosphate disodium
- Synonyms
- BETAMETHASONE SODIUM PHOSPHATE;BETAMETHASONE 21-DISODIUM PHOSPHATE;Durabetason;betnesol;bentelan;Celestan;Bentalan;NSC 90616;Vista-Methasone;Betamethasone 21-pho
- CBNumber
- CB5252688
- Molecular Formula
- C22H28FNa2O8P
- Formula Weight
- 516.4
- MOL File
- 151-73-5.mol
Betamethasone 21-phosphate disodium Property
- Melting point:
- 206-211°C
- alpha
- +98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
- storage temp.
- room temp
- solubility
- Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- form
- Solid
- color
- White to Off-White
- PH
- 7.5～9.0(5g/l, 25℃)
- Merck
- 14,1180
- Stability:
- Hygroscopic
- InChIKey
- PLCQGRYPOISRTQ-LWCNAHDDSA-L
- SMILES
- [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r|
- EPA Substance Registry System
- .beta.-Methasone disodium phosphate (151-73-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B7652
- Product name
- Betamethasone 21-phosphate disodium
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $372
- Updated
- 2024/03/01
- Product number
- 1068004
- Product name
- Betamethasone sodium phosphate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- B4110
- Product name
- Betamethasone 21-Phosphate Disodium Salt
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $223
- Updated
- 2024/03/01
- Product number
- B7652
- Product name
- Betamethasone 21-phosphate disodium
- Purity
- ≥97%
- Packaging
- 250mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- B1045000
- Product name
- Betamethasone sodium phosphate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- b1045000
- Price
- $220
- Updated
- 2024/03/01
Betamethasone 21-phosphate disodium Chemical Properties,Usage,Production
Indications and Usage
Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
Mechanisms of Action
Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.
Contraindications
Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.
Category
Toxic
Toxicity level
Medium
Acute toxicity
Oral administration - mice LD50: >4500 mg/kg
Flammability
Flammable; produces toxic fluoride fumes
Storage and transport
Store in a cool, ventilated, and dry place
Extinguishing agents
Dry powder, foam, sand, carbon dioxide, mist
Chemical Properties
White or almost white powder, very hygroscopic.
Uses
Nasal, Ophthalmic, Oral, Parenteral
Uses
Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
brand name
Celestone (Schering).
Biochem/physiol Actions
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.
Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.
Betamethasone 21-phosphate disodium Preparation Products And Raw materials
Raw materials
Preparation Products
Betamethasone 21-phosphate disodium Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
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- Country
- Japan
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- Japan
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- Country
- Japan
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View Lastest Price from Betamethasone 21-phosphate disodium manufacturers
- Product
- Betamethasone 21-phosphate disodium/Durabetason 151-73-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-07-31
- Product
- Betamethasone 21-phosphate disodium salt 151-73-5
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-03
- Product
- Betamethasone Sodium Phosphate 151-73-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-22