TAK875
- Product Name
- TAK875
- CAS No.
- 1000413-72-8
- Chemical Name
- TAK875
- Synonyms
- CS-54;TAK875;Fasiglifam;TAK-875,TAK875;TAK-875, >=98%;TAK875 USP/EP/BP;TAK-875(Fasiglifam);FASIGLIFAM (TAK-875);TAK-875; TAK875; TAK 875.;[(3S)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]-3-bi...
- CBNumber
- CB52534865
- Molecular Formula
- C29H32O7S
- Formula Weight
- 524.63
- MOL File
- 1000413-72-8.mol
TAK875 Property
- Melting point:
- 123-127°C
- Boiling point:
- 739.1±60.0 °C(Predicted)
- Density
- 1.252
- storage temp.
- Refrigerator
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 4.36±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17335
- Product name
- TAK-875
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17335
- Product name
- TAK-875
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 17335
- Product name
- TAK-875
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 17335
- Product name
- TAK-875
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- T004915
- Product name
- TAK-875
- Packaging
- 2.5mg
- Price
- $55
- Updated
- 2021/12/16
TAK875 Chemical Properties,Usage,Production
Description
The free fatty acid receptor 1 (FFAR1; GPR40) is highly expressed in pancreatic β-cells and activated by medium and long-chain fatty acids. There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential target for regulating diabetes, obesity, and other metabolic disorders. TAK-875 is a selective FFAR1 (GPR40) agonist (EC50 = 26 nM) that does not exhibit activity on the related FFARs FFAR2 (GPR43) or FFAR3 (GPR41).
Uses
TAK-876 is a selective G protein-coupled receptor 40 (GPR40) agonist (1,2). TAK-876 is a novel oral medication that has been developed to improve the secretion of insulin in a glucose-dependent manner, which has the potential to improve the control of blood sugar levels with a low risk of hypoglycemia.
Uses
TAK-876 is a selective G protein-coupled receptor 40 (GPR40) agonist. TAK-876 is a novel oral medication that has been developed to improve the secretion of insulin in a glucose-dependent manner, whic h has the potential to improve the control of blood sugar levels without the risk of hypoglycemia.
Definition
ChEBI: Fasiglifam is a member of biphenyls.
in vitro
tak-875 exhibited potent agonist activity and high binding affinity to the human receptor. in addition, tak-875 showed excellent agonist potency selectivity for gpr40 receptor over other members of the ffa receptor family (for which ec50>10 μm) [1].
in vivo
tak-875 showed potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female wistar fatty rats with impaired glucose tolerance [2].
target
GPR40
References
[1] negoro n, sasaki s, mikami s, ito m, suzuki m, tsujihata y, ito r, harada a, takeuchi k, suzuki n, miyazaki j, santou t, odani t, kanzaki n, funami m, tanaka t1, kogame a, matsunaga s, yasuma t, momose y. discovery of tak-875: a potent, selective, and orally bioavailable gpr40 agonist. acs med chem lett. 2010 jun 18;1(6):290-4.
[2] leifke e, naik h, wu j, viswanathan p, demanno d, kipnes m, vakilynejad m. a multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel gpr40 agonist, tak-875, in subjects with type 2 diabetes. clin pharmacol ther. 2012 jul;92(1):29-39.
TAK875 Preparation Products And Raw materials
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View Lastest Price from TAK875 manufacturers
- Product
- TAK875 1000413-72-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17