ChemicalBook > CAS DataBase List > PaloMid 529 (P529)

PaloMid 529 (P529)

Product Name
PaloMid 529 (P529)
CAS No.
914913-88-5
Chemical Name
PaloMid 529 (P529)
Synonyms
P529;CS-448;SG 00529;PaloMid 529;PaloMid 529 (P529);Palomid 529, >=98%;Palomid 529 - SG 00529;Palomid 529 (P529) /P529;Palomid 529, 10 mM in DMSO;PaloMid 529 (P529) USP/EP/BP
CBNumber
CB52546569
Molecular Formula
C24H22O6
Formula Weight
406.43
MOL File
914913-88-5.mol
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PaloMid 529 (P529) Property

Boiling point:
614.0±55.0 °C(Predicted)
Density 
1.280
storage temp. 
-20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
11.79±0.20(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
HP8756500
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0801
Product name
Palomid 529
Purity
≥98% (HPLC)
Packaging
5mg
Price
$76.95
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0801
Product name
Palomid 529
Purity
≥98% (HPLC)
Packaging
25mg
Price
$313
Updated
2025/07/31
Cayman Chemical
Product number
22706
Product name
Palomid 529
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
22706
Product name
Palomid 529
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
22706
Product name
Palomid 529
Purity
≥98%
Packaging
25mg
Price
$283
Updated
2024/03/01
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PaloMid 529 (P529) Chemical Properties,Usage,Production

Uses

Palomid 529 is a novel non-steroidal small molecule inhibitor

Biological Activity

Palomid 529 (P529) inhibits the mTORC1 and mTORC2 complexes and reduces the phosphorylation of pAktS473, pGSK3βS9 and pS6, but has no effect on pMAPK and pAktT308. Phase 1.

in vivo

Palomid 529 (200 mg/kg/2d) inhibits C6V10 glioma tumor growth in nude mice following i.p. dosing. Analysis of signaling within the tumor lysates reveals that Palomid 529 (P529) also reduces AktS473 but not AktT308 signaling[1]. Palomid 529 (RES-529) has shown antitumor activity in a variety of mouse models, including those for glioblastoma, and prostate and breast cancer. In a C6V10 glioblastoma subcutaneous xenograft model, mice pretreated with Palomid 529 (200 mg/kg/2 days, intraperitoneal) 1 week before and for 3 weeks after a tumor cell injection showed an ~70% decrease in tumor volume compared with the control. In another glioblastoma tumor model using human U87 cells, mice treated with micronized Palomid 529 3 days after a tumor cell injection showed a reduction in tumor growth by ~78 and 29% with 50 and 25 mg/kg/2 days, intraperitoneal, Palomid 529, respectively, after 24 days compared with the control[2]. Palomid 529 (P529) is able to reduce tumor growth in a dose-dependent manner both in PC3 and 22rv1 xenografts. A 10, 47.6, and 59.3% reduction of tumor mass is demonstrated in mice bearing PC3 xenografts receiving 50, 100, and 200 mg/kg Palomid 529 respectively and a 9, 38.7, and 51.5% reduction of tumor mass in mice bearing 22rv1 xenografts receiving 50, 100, and 200 mg/kg Palomid 529 respectively[3].

target

mTORC1

IC 50

TORC1; TORC2

PaloMid 529 (P529) Preparation Products And Raw materials

Raw materials

Preparation Products

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PaloMid 529 (P529) Suppliers

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View Lastest Price from PaloMid 529 (P529) manufacturers

Career Henan Chemical Co
Product
PaloMid 529 (P529) 914913-88-5
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

914913-88-5, PaloMid 529 (P529)Related Search:

4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE Propylamine MK-2206 2HCl Saracatinib OSI-027 DAPT 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde BEZ235 (NVP-BEZ235, Dactolisib)

  • PaloMid 529 (P529)
  • PaloMid 529
  • 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one
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  • 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one Palomid 529 (P529) SG 00529
  • SG 00529
  • Palomid 529, >=98%
  • Palomid 529, 98%, a novel potent inhibitor of both the mTORC1 and mTORC2
  • 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one
  • Palomid 529 - SG 00529
  • CS-448
  • P529; PALOMID529; P 529; PALOMID-529; P-529
  • 6H-Dibenzo[b,d]pyran-6-one, 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-
  • PaloMid 529 (P529) USP/EP/BP
  • Palomid 529 (P-529, SG00-529)
  • Palomid 529 (P529) /P529
  • Palomid 529, 10 mM in DMSO
  • P529
  • 914913-88-5
  • Inhibitors
  • API