Description
ChemicalBook > CAS DataBase List > 2-Acetylthiophene

2-Acetylthiophene

Description
Product Name
2-Acetylthiophene
CAS No.
88-15-3
Chemical Name
2-Acetylthiophene
Synonyms
Ethanone, 1-(2-thienyl)-;AKOS 91936;2-Acetylthioph;2-Acetothienone;2-Acetylthiophen;2-ACETYLTHIOLE;2-ACETOTHIOPHENE;-Acetylthiophene;2-ACETYLTHIOPHENE;AKOS BBS-00000940
CBNumber
CB5259889
Molecular Formula
C6H6OS
Formula Weight
126.18
MOL File
88-15-3.mol
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2-Acetylthiophene Property

Melting point:
10-11 °C (lit.)
Boiling point:
214 °C (lit.)
Density 
1.168 g/mL at 25 °C (lit.)
vapor pressure 
2.7 hPa (50 °C)
refractive index 
n20/D 1.565(lit.)
Flash point:
196 °F
storage temp. 
Store below +30°C.
solubility 
14g/l
form 
Liquid
color 
Clear pale yellow to light brown
Odor
at 100.00 %. sulfurous nutty hazelnut walnut
Odor Type
sulfurous
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
BRN 
107910
InChIKey
WYJOVVXUZNRJQY-UHFFFAOYSA-N
LogP
1.250
CAS DataBase Reference
88-15-3(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(2-thienyl)-(88-15-3)
EPA Substance Registry System
Ethanone, 1-(2-thienyl)- (88-15-3)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
25-23/24/25-20/21/22
Safety Statements 
45-38-36/37/39-28-36
RIDADR 
UN 2810 6.1/PG 2
WGK Germany 
3
RTECS 
OB6300000
F 
13
Autoignition Temperature
265 °C DIN 51794
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29349990
Toxicity
LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H311Toxic in contact with skin

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A22602
Product name
2-Acetylthiophene
Purity
98%
Packaging
25g
Price
$38
Updated
2023/06/20
Sigma-Aldrich
Product number
W503509
Product name
2-Acetylthiophene
Purity
≥98%, FG
Packaging
250g
Price
$173
Updated
2023/06/20
Sigma-Aldrich
Product number
W503509
Product name
2-Acetylthiophene
Purity
≥98%, FG
Packaging
1kg
Price
$521
Updated
2023/01/07
Sigma-Aldrich
Product number
8.00175
Product name
2-Acetylthiophene
Purity
for synthesis
Packaging
50mL
Price
$110
Updated
2023/01/07
Sigma-Aldrich
Product number
8.00175
Product name
2-Acetylthiophene
Purity
for synthesis
Packaging
250ML
Price
$450
Updated
2023/01/07
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2-Acetylthiophene Chemical Properties,Usage,Production

Description

2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.

Definition

ChEBI: 2-Acetylthiophene is an aromatic ketone.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.

Purification Methods

Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]

2-Acetylthiophene Preparation Products And Raw materials

Raw materials

Acetyl chloride

Preparation Products

5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 5-THIEN-2-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate N-(2-THIOPHENECARBOMYL)PYRIDINIUM BROMIDE 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 4-Bromo-2-thiophenecarboxylic acid 5-ACETYL-2-THIOPHENECARBALDEHYDE 2-Thiopheneacetic acid 2-(2-BROMOACETYL)THIOPHENE 2-(2-thienyl)propionic acid 1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER THIOPHENE-2-ACETAMIDE
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2-Acetylthiophene Suppliers

Americas 1 Belgium 3 Canada 2 China 475 Europe 4 France 4 Germany 14 Hungary 1 India 86 Italy 2 Japan 7 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 United Kingdom 22 United States 64 USA 1 Global 693
Clearsynth Labs Limited
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View Lastest Price from 2-Acetylthiophene manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-ACETYLTHIOPHENE 88-15-3
Price
US $1.00/PCS
Min. Order
1PCS
Purity
99%
Supply Ability
10 mt
Release date
2024-10-30
Hebei Weibang Biotechnology Co., Ltd
Product
2-Acetylthiophene 88-15-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Yanxi Chemical Co., Ltd.
Product
2-Acetylthiophene 88-15-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-11

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