ChemicalBook > CAS DataBase List > KGN

KGN

Product Name
KGN
CAS No.
4727-31-5
Chemical Name
KGN
Synonyms
KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;KGN Cells Line;Kartogenin(KGN);Kartogenin, 10 mM in DMSO;4'-Phenylphthalanilic Acid;CBFβ Activator, Kartogenin
CBNumber
CB52622751
Molecular Formula
C20H15NO3
Formula Weight
317.34
MOL File
4727-31-5.mol
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KGN Property

Melting point:
272 °C
Boiling point:
464.4±38.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >15mg/mL
form 
powder
pka
3.45±0.36(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
SLUINPGXGFUMLL-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-36-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0370
Product name
Kartogenin
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107.35
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0370
Product name
Kartogenin
Purity
≥98% (HPLC)
Packaging
25mg
Price
$453
Updated
2025/07/31
Sigma-Aldrich
Product number
420358
Product name
CBFβ Activator, Kartogenin
Purity
The CBFβ Activator, Kartogenin modulates the biological activity of CBFβ. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging
25 mg
Price
$145
Updated
2025/07/31
TCI Chemical
Product number
K0078
Product name
Kartogenin
Packaging
50MG
Price
$321
Updated
2025/07/31
Cayman Chemical
Product number
11826
Product name
Kartogenin
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
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KGN Chemical Properties,Usage,Production

Description

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

Uses

Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

in vivo

Kartogenin (10 μM in 4 μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice[1].

storage

+4°C

References

[1] KRISTEN JOHNSON. A Stem Cell–Based Approach to Cartilage Repair[J]. Science, 2012, 336 6082. DOI:10.1126/science.1215157

KGN Preparation Products And Raw materials

Raw materials

Preparation Products

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KGN Suppliers

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View Lastest Price from KGN manufacturers

Career Henan Chemical Co
Product
2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid 4727-31-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

4727-31-5, KGNRelated Search:

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  • 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
  • 2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
  • Kartogenin(KGN)
  • 4'-Phenylphthalanilic Acid
  • Kartogenin
  • KGN
  • 4′-Phenyl-phthalanilic acid (8CI)
  • n-Biphenyl-4-yl-phthalamic acid
  • 100822
  • CS-612
  • 2-[(4-phenylphenyl)carbamoyl]benzoic Acid
  • Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-
  • KGN USP/EP/BP
  • 2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
  • 2-(4-Biphenylylcarbamoyl)benzoic Acid
  • Kartogenin, stem cell differentiation
  • Kartogenin, 10 mM in DMSO
  • CBFβ Activator, Kartogenin
  • KGN Cells Line
  • 2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
  • 4727-31-5
  • Inhibitors
  • API