ChemicalBook > CAS DataBase List > KGN

KGN

Product Name
KGN
CAS No.
4727-31-5
Chemical Name
KGN
Synonyms
KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;Kartogenin(KGN);4'-Phenylphthalanilic Acid;n-Biphenyl-4-yl-phthalamic acid;4′-Phenyl-phthalanilic acid (8CI);2-(4-Biphenylylcarbamoyl)benzoic Acid
CBNumber
CB52622751
Molecular Formula
C20H15NO3
Formula Weight
317.34
MOL File
4727-31-5.mol
More
Less

KGN Property

Melting point:
272 °C
Boiling point:
464.4±38.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >15mg/mL
form 
powder
pka
3.45±0.36(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
SLUINPGXGFUMLL-UHFFFAOYSA-N
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
22-36-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2916310090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0370
Product name
Kartogenin
Purity
≥98% (HPLC)
Packaging
5mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0370
Product name
Kartogenin
Purity
≥98% (HPLC)
Packaging
25mg
Price
$441
Updated
2024/03/01
Cayman Chemical
Product number
11826
Product name
Kartogenin
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
11826
Product name
Kartogenin
Purity
≥98%
Packaging
10mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
11826
Product name
Kartogenin
Purity
≥98%
Packaging
25mg
Price
$261
Updated
2024/03/01
More
Less

KGN Chemical Properties,Usage,Production

Description

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

Uses

Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

storage

+4°C

References

1) Johnson et al. (2012), A stem cell-based approach to cartilage repair; Science, 336 717

KGN Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

KGN Suppliers

China 125 India 2 United Kingdom 3 United States 20 Global 150
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4573
Advantage
55
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1975
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
5930
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7295
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1925
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Wuxi KaideRui Pharmaceutical Technology Co., Ltd
Tel
19906241957
Fax
-
Email
1557216087@qq.com
Country
China
ProdList
1778
Advantage
55
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9374
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
15502154572
Fax
-
Email
yuben012@sina.com
Country
China
ProdList
505
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
More
Less

View Lastest Price from KGN manufacturers

Career Henan Chemical Co
Product
2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid 4727-31-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

4727-31-5, KGNRelated Search:

Dexamethasone SB 203580 Troglitazone LDN 193189 hydrochloride Amino alcohol Benzidine Y27632 (hydrochloride) SB 431542 Vismodegib (GDC-0449) 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline SB525334 L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

  • 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
  • 2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
  • Kartogenin(KGN)
  • 4'-Phenylphthalanilic Acid
  • Kartogenin
  • KGN
  • 2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid
  • 4′-Phenyl-phthalanilic acid (8CI)
  • n-Biphenyl-4-yl-phthalamic acid
  • 100822
  • CS-612
  • 2-[(4-phenylphenyl)carbamoyl]benzoic Acid
  • Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-
  • KGN USP/EP/BP
  • 2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
  • 2-(4-Biphenylylcarbamoyl)benzoic Acid
  • Kartogenin, stem cell differentiation
  • 4727-31-5
  • Inhibitors
  • API