Oprozomib
- Product Name
- Oprozomib
- CAS No.
- 935888-69-0
- Chemical Name
- Oprozomib
- Synonyms
- Axelopran;PR 047;CS-696;ONX-0912;OprozoMib;0prozomib;Oprozomib, >=98%;LY335979 ONX-0912;0prozoMib(ONX0912);ONX-0912(Oprozomib)
- CBNumber
- CB52628218
- Molecular Formula
- C25H32N4O7S
- Formula Weight
- 532.61
- MOL File
- 935888-69-0.mol
Oprozomib Property
- Melting point:
- 147-150°C (dec.)
- Boiling point:
- 849.9±65.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 12.29±0.46(Predicted)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 16269
- Product name
- ONX 0912
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16269
- Product name
- ONX 0912
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 16269
- Product name
- ONX 0912
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- O669700
- Product name
- Oprozomib
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- AG-CR1-3672-M001
- Product name
- Oprozomib[ONX0912]
- Purity
- ≥98%(HPLC)
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
Oprozomib Chemical Properties,Usage,Production
Description
ONX 0912 is an orally bioavailable proteasome inhibitor. It potently targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively). ONX 0912 inhibits the growth of multiple myeloma cells at nanomolar concentrations while not decreasing the viability of normal peripheral blood mononuclear cells at 1 μM. It blocks the growth of xenografted human multiple myeloma cells in mice when given orally. ONX 0912 has potential applications in certain types of cancer as well as other diseases that require proteasome activity.
Uses
Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.
Enzyme inhibitor
This orally active inhibitor (FW = 532.61 g/mol; CAS 935888-69-0; Solubility: 105 mg/mL DMSO, <1 mg/mL H2O), also known as ONX 0912 and O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)-ethyl]-Lserinamide, selectively targets the chymotrypsin-like (CT-L) activity of 20S proteasome β5 (IC50 = 36 nM) and 20S proteasome LMP7 (IC50 = 82 nM). In animal tumor model studies, ONX 0912 significantly reduced tumor progression and prolonged survival. Immununostaining of multiple myeloma tumors from ONX 0912-treated mice showed growth inhibition, apoptosis, and a decrease in associated angiogenesis. Oprozomib is distinct from carfilzomib, even though the same chemistry was employed to selectively target the proteasome. Oprozomib is under development as an oral therapy for hematologic malignancies, including multiple myeloma, and for patients with recurrent or refractory solid tumors (See also Carfilzomib).
target
20S proteasome β5
Oprozomib Preparation Products And Raw materials
Raw materials
Preparation Products
Oprozomib Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from Oprozomib manufacturers
- Product
- Oprozomib 935888-69-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Oprozomib 935888-69-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Oprozomib 935888-69-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09