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Trelagliptin

Product Name
Trelagliptin
CAS No.
865759-25-7
Chemical Name
Trelagliptin
Synonyms
Trilagliptin;YR-472;CS-926;Zafatek);Trelagliplin;Trelagliptin;Glass acid trigram;Trelagliptin, >=98%;SYR472 Trelagliptin;Trelagliptin(syr472)
CBNumber
CB52628490
Molecular Formula
C18H20FN5O2
Formula Weight
357.38
MOL File
865759-25-7.mol
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Trelagliptin Property

Boiling point:
519.0±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form 
solid
pka
9.88±0.20(Predicted)
InChI
InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey
IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES
C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18504
Product name
Trelagliptin
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
18504
Product name
Trelagliptin
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
18504
Product name
Trelagliptin
Purity
≥98%
Packaging
10mg
Price
$388
Updated
2024/03/01
TRC
Product number
T718780
Product name
Trelagliptin
Packaging
10mg
Price
$375
Updated
2021/12/16
TRC
Product number
A627965
Product name
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
Packaging
2.5mg
Price
$430
Updated
2021/12/16
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Trelagliptin Chemical Properties,Usage,Production

Uses

Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.

Definition

ChEBI: Trelagliptin is a member of benzenes and a nitrile.

Biological Activity

trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,

target

DPP-4

References

[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.

Trelagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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Trelagliptin Suppliers

China 219 India 5 United Kingdom 1 United States 13 Global 238
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View Lastest Price from Trelagliptin manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Trelagliptin 865759-25-7
Price
US $65.00-650.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-30
PNP Biotech Co. Ltd
Product
Trelagliptin 865759-25-7
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-10-17
Henan Bao Enluo International TradeCo.，LTD
Product
Trelagliptin 865759-25-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-05-12

865759-25-7, TrelagliptinRelated Search:

Trelagliptin Impurity 5 TrifluoroMethyl Dechloro Trelagliptin Impurity X (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzoic acid Trelagliptin succinate Trelagliptin Impurity 20 Trelagliptin IMpurity Icotinib Saxagliptin Pregabalin Ibrutinib Metformin Troglitazone Sofosbuvir Entospletinib (GS-9973) NVP-ADW742 ABT 263 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

  • Trelagliptin(syr472)
  • Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-
  • Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile
  • (S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
  • Trelagliptin Isomer Impurity
  • Trelagliptin, >=98%
  • Trelagliptin free base
  • Trelagliptin
  • 1-(2-broMo-5-fluorobenzyl)-6-chloro-3-MethylpriMidine-2,4(1H, 3H)-dione
  • Trelagliplin
  • (R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile
  • Trelagliptin impurity G
  • YR-472
  • (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)
  • (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2
  • 4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)
  • CS-926
  • SYR472 Trelagliptin
  • SYR-472; SYR472; SYR 472
  • Glass acid trigram
  • Trelagliptin Impurity 83
  • Trelagliptin/Trelagliptin succinate
  • TRELAGLIPTIN CAS 865759-25-7
  • 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
  • Zafatek)
  • Trilagliptin
  • TrelagliptinQ: What is Trelagliptin Q: What is the CAS Number of Trelagliptin Q: What is the storage condition of Trelagliptin Q: What are the applications of Trelagliptin
  • Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-flChemicalbookuoro-
  • Trelagliptin intermediate 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-
  • (S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile with 1/4 succinate
  • 865759-25-7
  • C18H20FN5O2
  • API
  • Trelagliptin
  • Inhibitors