ChemicalBook > CAS DataBase List > Trelagliptin

Trelagliptin

Product Name: Trelagliptin
CAS No.: 865759-25-7
Chemical Name: Trelagliptin
Synonyms: Trilagliptin;YR-472;CS-926;Zafatek);Trelagliplin;Trelagliptin;Glass acid trigram;Trelagliptin, >=98%;SYR472 Trelagliptin;13C,D3-Trelagliptin
CBNumber: CB52628490
Molecular Formula: C18H20FN5O2
Formula Weight: 357.38
MOL File: 865759-25-7.mol

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Trelagliptin Property

Boiling point:: 519.0±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form: solid
pka: 9.88±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey: IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES: C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 10mg
Price: $388
Updated: 2024/03/01

TRC

Product number: T718780
Product name: Trelagliptin
Packaging: 10mg
Price: $375
Updated: 2021/12/16

TRC

Product number: A627965
Product name: (S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
Packaging: 2.5mg
Price: $430
Updated: 2021/12/16

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Trelagliptin Chemical Properties,Usage,Production

Uses

Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.

Definition

ChEBI: Trelagliptin is a member of benzenes and a nitrile.

Biological Activity

trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,

in vivo

Trelagliptin (oral gavage; 7 mg/kg; single dose) shows sustained PD effect in dogs and gives >80% inhibition of DPP-4 activity even after 24h^[1].Trelagliptin (oral gavage; 3 mg/kg; single dose; 60 min prior to oral glucose) significantly improves the glucose tolerance capacity by decreasing the AUC_0?120min of 19.3% compared with the vehicle group in ob/ob mice^[3]. Trelagliptin (oral gavage; 10 mg/kg; once a week; 8 weeks) caused significant reductions in fasting blood glucose (FBG) levels, and the average reduction during the entire treatment period is 16.8% compared to the control.It also increases insulin level and raised it by 1.7-fold in AUC_0?120min in ob/ob mice^[3].

Animal Model:	ICR ob/ob mice^[3]
Dosage:	10 mg/kg
Administration:	Oral gavage; 10 mg/kg; once a week; 8 weeks
Result:	Exerted chronic antidiabetic effects on type 2 diabetic db/db Mice.

target

DPP-4

IC 50

DPP-4

References

[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.

Trelagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trelagliptin manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Trelagliptin 865759-25-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Trelagliptin 865759-25-7
Price: US $65.00-650.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-30

PNP Biotech Co. Ltd

Product: Trelagliptin 865759-25-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-10-17

865759-25-7, TrelagliptinRelated Search:

Trelagliptin Impurity 5 TrifluoroMethyl Dechloro Trelagliptin Impurity X (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzoic acid Trelagliptin succinate Trelagliptin Impurity 20 Trelagliptin IMpurity Icotinib Saxagliptin Pregabalin Ibrutinib Metformin Troglitazone Sofosbuvir Entospletinib (GS-9973) NVP-ADW742 ABT 263 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Trelagliptin(syr472)

Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-

Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile

(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile

Trelagliptin Isomer Impurity

Trelagliptin, >=98%

Trelagliptin free base

Trelagliptin

1-(2-broMo-5-fluorobenzyl)-6-chloro-3-MethylpriMidine-2,4(1H, 3H)-dione

Trelagliplin

(R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile

Trelagliptin impurity G

YR-472

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2

4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)

CS-926

SYR472 Trelagliptin

SYR-472; SYR472; SYR 472

Glass acid trigram

Trelagliptin Impurity 83

Trelagliptin/Trelagliptin succinate

TRELAGLIPTIN CAS 865759-25-7

2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile

Zafatek)

Trilagliptin

TrelagliptinQ: What is Trelagliptin Q: What is the CAS Number of Trelagliptin Q: What is the storage condition of Trelagliptin Q: What are the applications of Trelagliptin

Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-flChemicalbookuoro-

Trelagliptin intermediate 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-

(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile with 1/4 succinate

Dioxo-1 (2H) - pyrimidinyl) methyl] -4-

Trelagliptin, 10 mM in DMSO

13C,D3-Trelagliptin

865759-25-7

C18H20FN5O2

API

Trelagliptin

Inhibitors