2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Product Name: 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
CAS No.: 1374356-45-2
Chemical Name: 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
Synonyms: (s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;(S)-crizotinib, 10 mM in DMSO
CBNumber: CB12729650
Molecular Formula: C21H22Cl2FN5O
Formula Weight: 450.34
MOL File: 1374356-45-2.mol

More

Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Property

Boiling point:: 599.2±50.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
form: A solid
pka: 9.81±0.10(Predicted)
color: Light yellow to yellow
InChI: 1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
InChIKey: KTEIFNKAUNYNJU-LBPRGKRZSA-N
SMILES: ClC1=C([C@H](C)OC2=C(N)N=CC(C3=CN(C4CCNCC4)N=C3)=C2)C(Cl)=C(F)C=C1
CAS DataBase Reference: 1374356-45-2

More

Less

Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 6025
Product name: (S)-Crizotinib
Purity: ≥98%(HPLC)
Packaging: 10
Price: $137
Updated: 2021/12/16

Tocris

Product number: 6025
Product name: (S)-Crizotinib
Purity: ≥98%(HPLC)
Packaging: 50
Price: $578
Updated: 2021/12/16

TRC

Product number: C785005
Product name: (S)-Crizotinib
Packaging: 5mg
Price: $275
Updated: 2021/12/16

TRC

Product number: C785005
Product name: (S)-Crizotinib
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

TRC

Product number: C785005
Product name: (S)-Crizotinib
Packaging: 1mg
Price: $80
Updated: 2021/12/16

More

Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Usage,Production

Characteristics

MTH1 (NUDT1)-selective inhibitor.

Uses

(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.

Definition

ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.

Biological Activity

(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

target

Target	Value
MTH1 (Cell-free assay)	72 nM

storage

Store at RT

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers

China 91 India 3 United Kingdom 2 United States 13 Global 109

Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4790
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-68651977
Email: 2310993908@qq.com
Country: China
ProdList: 2917
Advantage: 58

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2519
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

More

Less

View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers

Career Henan Chemical Co

Product: 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

1374356-45-2, 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-Related Search:

Lead Selenium Diethyl sulfate LEUHISTIN Angeli’s Salt Lignosulfonic acid Everolimus KU-55933 (ATM Kinase Inhibitor) Sunitinib Malate Crizotinib TH588 AZD-9291

(S)-CRIZOTINIB

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Crizotinib impurity A

Crizotinib S-Isomer

Crizotinib Impurity 24

3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Crizotinib, (S)-

ent-crizotinib

CRIZOTINIB CHIRAL IMPURITY

(s)-g-fitinib

mutT,inhibit,nucleotide,Apoptosis,(S) crizotinib,homologue,Inhibitor,activity,anticancer,pool,(S)-Crizotinib,(S)crizotinib,DNA/RNA Synthesis

CRIZOTINIB, S-ENANTIOMER

(S)-crizotinib, 10 mM in DMSO

1374356-45-2

Inhibitors