Trelagliptin
- Product Name
- Trelagliptin
- CAS No.
- 865759-25-7
- Chemical Name
- Trelagliptin
- Synonyms
- Trilagliptin;YR-472;CS-926;Zafatek);Trelagliplin;Trelagliptin;Glass acid trigram;Trelagliptin, >=98%;SYR472 Trelagliptin;13C,D3-Trelagliptin
- CBNumber
- CB52628490
- Molecular Formula
- C18H20FN5O2
- Formula Weight
- 357.38
- MOL File
- 865759-25-7.mol
Trelagliptin Property
- Boiling point:
- 519.0±60.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
- form
- solid
- pka
- 9.88±0.20(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
- InChIKey
- IWYJYHUNXVAVAA-OAHLLOKOSA-N
- SMILES
- C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18504
- Product name
- Trelagliptin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 18504
- Product name
- Trelagliptin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 18504
- Product name
- Trelagliptin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $388
- Updated
- 2024/03/01
- Product number
- T718780
- Product name
- Trelagliptin
- Packaging
- 10mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- A627965
- Product name
- (S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
- Packaging
- 2.5mg
- Price
- $430
- Updated
- 2021/12/16
Trelagliptin Chemical Properties,Usage,Production
Uses
Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.
Definition
ChEBI: Trelagliptin is a member of benzenes and a nitrile.
Biological Activity
trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,
in vivo
Trelagliptin (oral gavage; 7 mg/kg; single dose) shows sustained PD effect in dogs and gives >80% inhibition of DPP-4 activity even after 24h[1].Trelagliptin (oral gavage; 3 mg/kg; single dose; 60 min prior to oral glucose) significantly improves the glucose tolerance capacity by decreasing the AUC0?120min of 19.3% compared with the vehicle group in ob/ob mice[3]. Trelagliptin (oral gavage; 10 mg/kg; once a week; 8 weeks) caused significant reductions in fasting blood glucose (FBG) levels, and the average reduction during the entire treatment period is 16.8% compared to the control.It also increases insulin level and raised it by 1.7-fold in AUC0?120min in ob/ob mice[3].
| Animal Model: | ICR ob/ob mice[3] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; 10 mg/kg; once a week; 8 weeks |
| Result: | Exerted chronic antidiabetic effects on type 2 diabetic db/db Mice. |
target
DPP-4
IC 50
DPP-4
References
[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.
Trelagliptin Preparation Products And Raw materials
Raw materials
Preparation Products
Trelagliptin Suppliers
- Tel
- --
- Fax
- --
- sales4@cleanchemlab.com
- Country
- India
- ProdList
- 325
- Advantage
- 58
- Tel
- --
- Fax
- --
- mktg@pharmaffiliates.com
- Country
- India
- ProdList
- 6739
- Advantage
- 58
View Lastest Price from Trelagliptin manufacturers
- Product
- Trelagliptin 865759-25-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- Trelagliptin 865759-25-7
- Price
- US $65.00-650.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30
- Product
- Trelagliptin 865759-25-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-10-17