ChemicalBook > CAS DataBase List > 5-AMino-2,4-di-tert-butylphenol

5-AMino-2,4-di-tert-butylphenol

Product Name
5-AMino-2,4-di-tert-butylphenol
CAS No.
873055-58-4
Chemical Name
5-AMino-2,4-di-tert-butylphenol
Synonyms
VX-770 intermediate;IvacaftorIntermediateA;4,6-dichloropyridazin-4-ol;2,4-ditert-butyl-5-aminophenol;5-AMino-2,4-di-tert-butylphenol;5-Amino-2,4-ditertiarybutyphenol;5-Amino-2,4-ditertiarybutylphenol;5-Amino-2,4-bis(2-methyl-2-propanyl)phenol;Phenol, 5-amino-2,4-bis(1,1-dimethylethyl)-;2,4-Di-tert-butyl-5-aMinophenyl Methyl carbonate
CBNumber
CB52637683
Molecular Formula
C14H23NO
Formula Weight
221.34
MOL File
873055-58-4.mol
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5-AMino-2,4-di-tert-butylphenol Property

Boiling point:
319.7±30.0 °C(Predicted)
Density 
0.990±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
11.63±0.23(Predicted)
Appearance
Off-white to pink Solid
InChI
InChI=1S/C14H23NO/c1-13(2,3)9-7-10(14(4,5)6)12(16)8-11(9)15/h7-8,16H,15H2,1-6H3
InChIKey
BKSDHPHOWDUJNB-UHFFFAOYSA-N
SMILES
C1(O)=CC(N)=C(C(C)(C)C)C=C1C(C)(C)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A604628
Product name
5-Amino-2,4-di-tert-butylphenol
Packaging
100mg
Price
$295
Updated
2021/12/16
TRC
Product number
A604628
Product name
5-Amino-2,4-di-tert-butylphenol
Packaging
250mg
Price
$605
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0386179
Product name
5-AMINO-2,4-DI-TERT-BUTYLPHENOL
Purity
95.00%
Packaging
5MG
Price
$500.94
Updated
2021/12/16
Ambeed
Product number
A601459
Product name
5-Amino-2,4-di-tert-butylphenol
Purity
95+%
Packaging
100mg
Price
$40
Updated
2021/12/16
Ambeed
Product number
A601459
Product name
5-Amino-2,4-di-tert-butylphenol
Purity
95+%
Packaging
250mg
Price
$58
Updated
2021/12/16
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5-AMino-2,4-di-tert-butylphenol Chemical Properties,Usage,Production

Uses

5-Amino-2,4-di-tert-butylphenol is an intermediate used in the preparation of ivacaftor via condensation of oxo dihydroquinoline carboxylic acid with amino ditert butylphenol.

Synthesis

To a refluxing solution of 2,4-di-tert-butyl-5-nitro-phenol (1.86 g, 7.40 mmol) and ammonium formate (1.86 g) in ethanol (75 mL) was added Pd-5% wt on activated carbon (900 mg). The reaction mixture was stirred at reflux for 2 h, cooled to room temperature, and filtered through Celite. The Celite was washed with methanol, and the combined filtrates were concentrated to yield 5-amino-2,4-di-tert-butyl-phenol as a grey solid (1.66 g, quant.).

5-AMino-2,4-di-tert-butylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMino-2,4-di-tert-butylphenol Suppliers

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View Lastest Price from 5-AMino-2,4-di-tert-butylphenol manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-AMino-2,4-di-tert-butylphenol 873055-58-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-14
Career Henan Chemical Co
Product
5-Amino-2,4-di-tert-butylphenol 873055-58-4
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

873055-58-4, 5-AMino-2,4-di-tert-butylphenolRelated Search:

2,4-di-tert-butyl-5-nitrophenyl methyl carbonate 4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro- 2-PHENYLAMINOMETHYLENE-MALONIC ACIDDIETHYL ESTER 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID VX-770

  • 5-AMino-2,4-di-tert-butylphenol
  • 2,4-Di-tert-butyl-5-aMinophenyl Methyl carbonate
  • Phenol, 5-amino-2,4-bis(1,1-dimethylethyl)-
  • 4,6-dichloropyridazin-4-ol
  • 5-Amino-2,4-ditertiarybutyphenol
  • 5-Amino-2,4-bis(2-methyl-2-propanyl)phenol
  • VX-770 intermediate
  • 5-amino-2,4-di-tert-butylphenol hydrochloride (base)
  • 5-Amino-2,4-ditertiarybutylphenol
  • 2,4-ditert-butyl-5-aminophenol
  • 5-Amino-2,4-di-tert-butyl-phenol (Ivacaftor intermediate)
  • IvacaftorIntermediateA
  • 873055-58-4
  • 973055-58-4