5-AMino-2,4-di-tert-butylphenol
- Product Name
- 5-AMino-2,4-di-tert-butylphenol
- CAS No.
- 873055-58-4
- Chemical Name
- 5-AMino-2,4-di-tert-butylphenol
- Synonyms
- VX-770 intermediate;4,6-dichloropyridazin-4-ol;2,4-ditert-butyl-5-aminophenol;5-AMino-2,4-di-tert-butylphenol;5-Amino-2,4-ditertiarybutyphenol;5-Amino-2,4-ditertiarybutylphenol;5-Amino-2,4-bis(2-methyl-2-propanyl)phenol;Phenol, 5-amino-2,4-bis(1,1-dimethylethyl)-;2,4-Di-tert-butyl-5-aMinophenyl Methyl carbonate;5-amino-2,4-di-tert-butylphenol hydrochloride (base)
- CBNumber
- CB52637683
- Molecular Formula
- C14H23NO
- Formula Weight
- 221.34
- MOL File
- 873055-58-4.mol
5-AMino-2,4-di-tert-butylphenol Property
- Boiling point:
- 319.7±30.0 °C(Predicted)
- Density
- 0.990±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 11.63±0.23(Predicted)
- InChI
- InChI=1S/C14H23NO/c1-13(2,3)9-7-10(14(4,5)6)12(16)8-11(9)15/h7-8,16H,15H2,1-6H3
- InChIKey
- BKSDHPHOWDUJNB-UHFFFAOYSA-N
- SMILES
- C1(O)=CC(N)=C(C(C)(C)C)C=C1C(C)(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A604628
- Product name
- 5-Amino-2,4-di-tert-butylphenol
- Packaging
- 100mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- A604628
- Product name
- 5-Amino-2,4-di-tert-butylphenol
- Packaging
- 250mg
- Price
- $605
- Updated
- 2021/12/16
- Product number
- CHM0386179
- Product name
- 5-AMINO-2,4-DI-TERT-BUTYLPHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.94
- Updated
- 2021/12/16
- Product number
- CC00-7587
- Product name
- 5-Amino-2,4-di-tert-butyl-phenol
- Purity
- 95%
- Packaging
- 25g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- A601459
- Product name
- 5-Amino-2,4-di-tert-butylphenol
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
5-AMino-2,4-di-tert-butylphenol Chemical Properties,Usage,Production
Uses
5-Amino-2,4-di-tert-butylphenol is an intermediate used in the preparation of ivacaftor via condensation of oxo dihydroquinoline carboxylic acid with amino ditert butylphenol.
Synthesis
To a refluxing solution of 2,4-di-tert-butyl-5-nitro-phenol (1.86 g, 7.40 mmol) and ammonium formate (1.86 g) in ethanol (75 mL) was added Pd-5% wt on activated carbon (900 mg). The reaction mixture was stirred at reflux for 2 h, cooled to room temperature, and filtered through Celite. The Celite was washed with methanol, and the combined filtrates were concentrated to yield 5-amino-2,4-di-tert-butyl-phenol as a grey solid (1.66 g, quant.).
5-AMino-2,4-di-tert-butylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
5-AMino-2,4-di-tert-butylphenol Suppliers
View Lastest Price from 5-AMino-2,4-di-tert-butylphenol manufacturers
- Product
- 5-Amino-2,4-di-tert-butylphenol 873055-58-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26