3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

ChemicalBook > CAS DataBase List > 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

Product Name: 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
CAS No.: 420831-40-9
Chemical Name: 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
Synonyms: AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
CBNumber: CB52639218
Molecular Formula: C19H21BrN2O3S
Formula Weight: 437.35
MOL File: 420831-40-9.mol

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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Property

Density: 1.469±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥15mg/mL
form: powder
pka: 12.28±0.70(Predicted)
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0152
Product name: AK-7
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0152
Product name: AK-7
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $451
Updated: 2024/03/01

Cayman Chemical

Product number: 14004
Product name: AK-7
Purity: ≥95%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14004
Product name: AK-7
Purity: ≥95%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 14004
Product name: AK-7
Purity: ≥95%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties,Usage,Production

Description

The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC₅₀ = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.

Uses

AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.

storage

+4°C

References

1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540 2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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420831-40-9, 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMideRelated Search:

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