ChemicalBook > CAS DataBase List > Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
- Product Name
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
- CAS No.
- 83249-10-9
- Chemical Name
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
- Synonyms
- 3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid;3-methoxycarbonylbicyclo[1.1.1]pentane-1-carboxylate;112657;o[1.1.1]pentane-1-carboxyL;1-Methyl bicyclo[1.1.1]pentane-1,3- dicarboxylate;Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, 1-Methyl ester;Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester;Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid 1-Monomethyl Ester;Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, monomethyl este...;1,1'-Bicyclo[1,1,1]pentane-1,3-dicarboxylic acid monomethyl ester
- CBNumber
- CB52639854
- Molecular Formula
- C8H10O4
- Formula Weight
- 170.16
- MOL File
- 83249-10-9.mol
More
Less
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Property
- Melting point:
- 138-139 °C(Solv: chloroform (67-66-3); heptane (142-82-5))
- Boiling point:
- 272.2±40.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 4.50±0.40(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C8H10O4/c1-12-6(11)8-2-7(3-8,4-8)5(9)10/h2-4H2,1H3,(H,9,10)
- InChIKey
- UJZHYIMESNWEQA-UHFFFAOYSA-N
- SMILES
- C12(C(OC)=O)CC(C(O)=O)(C1)C2
More
Less
Safety
- RIDADR
- UN2811
- HS Code
- 2917198090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHB00015
- Product name
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, 1-methyl ester
- Purity
- AldrichCPR
- Packaging
- 100 mg
- Price
- $550
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3149
- Product name
- 3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic Acid
- Packaging
- 200MG
- Price
- $161
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3149
- Product name
- 3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic Acid
- Packaging
- 1G
- Price
- $484
- Updated
- 2025/07/31
TRC
- Product number
- B382905
- Product name
- Bicyclo[1.1.1]pentane-1,3-dicarboxylicAcid,1-methylEster
- Packaging
- 250mg
- Price
- $875
- Updated
- 2021/12/16
TRC
- Product number
- B382905
- Product name
- Bicyclo[1.1.1]pentane-1,3-dicarboxylicAcid,1-methylEster
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
More
Less
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Chemical Properties,Usage,Production
Uses
Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid, 1-methyl Ester acts as a reagent for the synthesis and in the biopharmaceutical evaluation of imatinib analogs. Also functions as a reagent for the preparation and in biological evaluation of novel bicyclo[1.1.1]pentane-based acidic amino acids as glutamate receptors ligands It is a COVID19-related research product.
Synthesis
5781-53-3
35634-10-7
83249-10-9
The general procedure for the synthesis of methyl bicyclo[1.1.1]pentane-1-carboxylate-3-carboxylate from oxalyl chloride monomethyl ester and the compound (CAS:35634-10-7) was as follows: first, a solution of [1.1.1]propeller in Et2O (500 mL; 161 mmol, 1 eq.) was prepared independently, along with ethyl chloroacetate (16.3 mL, 177 mmol, 1.1 eq.) solution in Et2O (49.7 mL). The entire reactor was flushed for 5 min using pure Et2O (pump 1: 4.0 mL/min, pump 2: 0.5 mL/min). Subsequently, a solution of reagent (2) was injected at a flow rate of 4.0 mL/min at 0 to -80 °C, followed by a solution of reagent (3) at a flow rate of 0.5 mL/min at room temperature. The photoreactor was placed in an ice bath (volume 58 mL; FEP tube rotated over a lamp). After the reaction mixture left the photoreactor, it was quenched using an alkaline aqueous solution of NaOH, KOH, NaHCO3, or KHCO3. After vigorous stirring for 2 h, the aqueous layer was separated and acidified to pH = 1. Subsequently, the mixture was extracted with DCM (3 × 500 mL). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to afford 3-(methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid (9, 17.5 g, 103 mmol, 63% yield), the product being a pale yellow solid.
References
[1] Patent: WO2017/157932, 2017, A1. Location in patent: Page/Page column 27
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester Suppliers
- Tel
- 19155667820
- sales@nuoquanpharm.com
- Country
- China
- ProdList
- 114
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 022-66211289808-808 13672102692
- contact@sphinxpharm.com
- Country
- China
- ProdList
- 138
- Advantage
- 58
- Tel
- 18918657159
- sales-Aigen@lianhetech.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 4000255188 13327728092
- sales@pharmablock.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0531-88803958 18866891188
- Fax
- 0531-82777287
- 18853169188@163.com
- Country
- China
- ProdList
- 193
- Advantage
- 58
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 18112588827
- sales4@sepharm.com.cn
- Country
- China
- ProdList
- 285
- Advantage
- 60
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 021-50426030 13856289449
- Fax
- 021-50426030
- 2630597085@qq.com
- Country
- China
- ProdList
- 1889
- Advantage
- 55
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 4053
- Advantage
- 60
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 021-31761238 13167072949
- Fax
- 021-31761238
- 3146446224@qq.com
- Country
- China
- ProdList
- 1379
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 17836913271
- Fax
- 0374-8348899
- 3224305243@qq.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- 021-50929289 18616309303
- Fax
- -
- sales@ypptech.com.cn
- Country
- China
- ProdList
- 287
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 8596
- Advantage
- 58
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- 0512-6956-1983
- info@xenoah.com
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 2559355526@qq.com
- Country
- China
- ProdList
- 14193
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 025-57027686 17372956142
- Fax
- 025-57027686
- li_lan@syntitan.com
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 021-000000 13917643586;
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9856
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 2274
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 18916696128
- service@snowpharm.com
- Country
- China
- ProdList
- 1369
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 021-67121386, 800-988-0390
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 5391
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- +8615866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 8497
- Advantage
- 58
More
Less
View Lastest Price from Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester 83249-10-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-19
Career Henan Chemical Co
- Product
- Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester 83249-10-9
- Price
- US $1.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2019-12-17
83249-10-9, Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl esterRelated Search:
Bicyclo[3.1.0]hexan-3-ol
Bicyclo[1.1.1]pentane-1-carboxylic acid, methyl ester (9CI)
4-Aminobenzocyclobutene
4-Hydroxymethylbenzocyclobutene
4-Carboxylbenzocyclobutene
bicyclo[1.1.1]pentane-1,3-dicarbonitrile
Bicyclo[1.1.1]pentane-1-sulfonamide
Bicyclo[1.1.1]pentane-1,3-dicarboxamide
Bicyclo[1.1.1]pentane-1-carboxamide
5-Norbornene-2-carbonitrile
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
2,2,4-Trimethylpentane
Trimethoxymethane
2-Methylbutane
Metaclazepam
Methyl 1,2,4-triazole-3-carboxylate
Bicyclo[1.1.1]pentan-1-amine
bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride