ChemicalBook > CAS DataBase List > RVX-208

RVX-208

Product Name
RVX-208
CAS No.
1044870-39-4
Chemical Name
RVX-208
Synonyms
CS-686;CS-1815;RVX-208;RVX-000222;Apabetalone;RVX-208 USP/EP/BP;RVX-208(RVX000222);RVX-208(RVX 000222);Apabetalone-RVX-208;Apabetalone (RVX-08, RVX-000222)
CBNumber
CB52640278
Molecular Formula
C20H22N2O5
Formula Weight
370.4
MOL File
1044870-39-4.mol
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RVX-208 Property

Boiling point:
594.2±60.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
-20°C (des.)
solubility 
Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form 
solid
pka
14.21±0.10(Predicted)
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16424
Product name
RVX-208
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16424
Product name
RVX-208
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16424
Product name
RVX-208
Purity
≥98%
Packaging
10mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
16424
Product name
RVX-208
Purity
≥98%
Packaging
25mg
Price
$404
Updated
2024/03/01
TRC
Product number
R800000
Product name
RVX208
Packaging
25mg
Price
$330
Updated
2021/12/16
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RVX-208 Chemical Properties,Usage,Production

Description

The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.

Uses

RVX-208 is a selective antagonist of bromodomain and extra terminal (BET)’s bromodomains.

target

BD2

References

1) Picaud?et al. (2013),?RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA,?110?19754 2) McLure?et al. (2013),?RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One,?8e83190 3) Bailey?et al. (2010),?RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol.,?55?2580 4) Jahagirdar?et al. (2014),?A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis,?236?91

RVX-208 Preparation Products And Raw materials

Raw materials

Preparation Products

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RVX-208 Suppliers

China 153 India 3 The Netherlands 1 United Kingdom 1 United States 17 Global 175
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View Lastest Price from RVX-208 manufacturers

Career Henan Chemical Co
Product
RVX-208 1044870-39-4
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

1044870-39-4, RVX-208Related Search:

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  • 2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one
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  • 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208
  • RVX-208
  • Apabetalone
  • Apabetalone-RVX-208
  • RVX-208(RVX 000222)
  • RVX-208(RVX000222)
  • CS-1815
  • APABETALONE; RVX-000222; RVX208; RVX 208; RVX000222; RVX 000222
  • CS-686
  • RVX-208 USP/EP/BP
  • Apabetalone (RVX-08, RVX-000222)
  • Apabetalone (RVX-208, RVX-000222)
  • 2-(4-(2-Hydroxyethoxy)-2,6-dimethylphenyl)-6,8-dimethoxyquinazolin-4(3H)-one
  • 1044870-39-4
  • Inhibitors
  • API