1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-

Product Name: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-
CAS No.: 139756-04-0
Chemical Name: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-
Synonyms: Udenafil Impurity 12;Sildenafil Impurity 56;1-Methyl-4-(2-n-propoxybenzamido)-3-n-propylpyrazole-5-carboxamide;1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide;2-methyl-4-[(2-propoxybenzoyl)amino]-5-propylpyrazole-3-carboxamide;4-(2-Propoxybenzoylamino)-1-methyl-3-propyl-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-;2-Methyl-4-(2-propoxy-benzoylamino)-5-propyl-2h-pyrazole-3-carboxylic acid amide;1-Methyl-4-(2-propoxy-benzcarboxcarboxcarboxamido)-3-propyl-1H-pyrazol-5-carboxamide;3-[[[5-(AMinocarbonyl)-1-Methyl-3-propyl-1H-pyrazol-4-yl]aMino]carbonyl]-4-propoxybenzene
CBNumber: CB52652114
Molecular Formula: C18H24N4O3
Formula Weight: 344.41
MOL File: 139756-04-0.mol

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1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- Property

Melting point:: >140°C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C18H24N4O3/c1-4-8-13-15(16(17(19)23)22(3)21-13)20-18(24)12-9-6-7-10-14(12)25-11-5-2/h6-7,9-10H,4-5,8,11H2,1-3H3,(H2,19,23)(H,20,24)
InChIKey: OYHROMDBMGIQCJ-UHFFFAOYSA-N
SMILES: N1(C)C(C(N)=O)=C(NC(=O)C2=CC=CC=C2OCCC)C(CCC)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A603105
Product name: 3-[[[5-(Aminocarbonyl)-1-methyl-3-propyl-1H-pyrazol-4-yl]amino]carbonyl]-4-propoxybenzene
Packaging: 100mg
Price: $150
Updated: 2021/12/16

TRC

Product number: A603105
Product name: 3-[[[5-(Aminocarbonyl)-1-methyl-3-propyl-1H-pyrazol-4-yl]amino]carbonyl]-4-propoxybenzene
Packaging: 1g
Price: $1190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002129
Product name: 3-[[[5-(AMINOCARBONYL)-1-METHYL-3-PROPYL-1H-PYRAZOL-4-YL]AMINO]CARBONYL]-4-PROPOXYBENZENE
Purity: 95.00%
Packaging: 5MG
Price: $505.76
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 53728
Product name: 3-[[[5-(Aminocarbonyl)-1-methyl-3-propyl-1H-pyrazol-4-yl]amino]carbonyl]-4-propoxybenzene
Packaging: 100mg
Price: $650
Updated: 2021/12/16

Chemenu

Product number: CM249256
Product name: 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide
Purity: 95%
Packaging: 25g
Price: $153
Updated: 2021/12/16

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1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Uses

Intermediate in the preparation of Sildenafil (S435000) analogues.

Synthesis

2100-31-4

139756-02-8

139756-04-0

Step 8 Synthesis of 2-methyl-4-(2-propoxybenzoylamino)-5-propyl-2H-pyrazole-3-carboxamide: 2-Propoxybenzoic acid (13.7 g, 76.1 mmol) was mixed with thionyl chloride (36.2 g, 304.4 mmol) in anhydrous dichloromethane (80 mL) and heated at reflux for 3 hours. Upon completion of the reaction, the solvent and excess thionyl chloride were removed by distillation under reduced pressure. The resulting chloride intermediate was dissolved in anhydrous dichloromethane (60 mL) and slowly added to an anhydrous solution containing 4-amino-2-methyl-5-propyl-2H-pyrazole-3-carboxamide (12.6 g, 69.2 mmol), dry triethylamine (7 g, 69.2 mmol), and 4-(N,N-dimethylamino)pyridine (84.5 mg, 0.7 mmol). dichloromethane (200 mL) solution, maintaining the reaction temperature at 0°C. After stirring the reaction mixture for 1 h, it was washed sequentially with water (150 mL), saturated aqueous sodium carbonate solution (200 mL) and saturated brine (200 mL). The organic layer was dried over anhydrous magnesium sulfate and filtered, the filtrate was concentrated to about 60 mL and a white solid product (22 g, 92% yield) was precipitated by addition of hexane (150 mL). The product was confirmed by 1H NMR (300 MHz, CDCl3) and LC-MS (m/z = 345 [M + H]+) characterization.

References

[1] Patent: US2008/194529, 2008, A1. Location in patent: Page/Page column 57-58
[2] Patent: US2003/176696, 2003, A1

1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- Preparation Products And Raw materials

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1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- Suppliers

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Nanjing shengyilai Chemical Co., Ltd

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View Lastest Price from 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl- 139756-04-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Shaanxi Dideu Medichem Co. Ltd

Product: 2-methyl-4-[(2-propoxybenzoyl)amino]-5-propylpyrazole-3-carboxamide 139756-04-0
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide 139756-04-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-14

139756-04-0, 1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-Related Search:

3',5'-di-o-p-chlorobenzoyl-2-deoxy-5-azacytosine Ethyl 3-n-propylpyrazole-5-carboxylate SILDENAFIL-D8 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide ETHYL 5-ISOPROPYLPYRAZOLE-3-CARBOXYLATE 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Sildenafil Impurity 25 1-METHYL-3-(2-METHYLPROPYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Sildenafil DiMer IMpurity ETHYL 2,4-DIOXOHEPTANOATE 1-METHYL-3-ISOPROPYL-1H-PYRAZOLE-5-CARBOXYLICACID 5-CHLOROSULFONYL-2-ETHOXYBENZOIC ACID 2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]BENZOIC ACID INTERMEDIATES 2-tirfluoromethylpyridine DYES INTERMEDIATES

1H-Pyrazole-5-carboxaMide, 1-Methyl-4-[(2-propoxybenzoyl)aMino]-3-propyl-

3-[[[5-(AMinocarbonyl)-1-Methyl-3-propyl-1H-pyrazol-4-yl]aMino]carbonyl]-4-propoxybenzene

2-methyl-4-[(2-propoxybenzoyl)amino]-5-propylpyrazole-3-carboxamide

1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide

1-Methyl-4-(2-n-propoxybenzamido)-3-n-propylpyrazole-5-carboxamide

2-Methyl-4-(2-propoxy-benzoylamino)-5-propyl-2h-pyrazole-3-carboxylic acid amide

4-(2-Propoxybenzoylamino)-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Sildenafil Impurity 56

Udenafil Impurity 12

1-Methyl-4-(2-propoxy-benzcarboxcarboxcarboxamido)-3-propyl-1H-pyrazol-5-carboxamide

139756-04-0

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