EpiMedokoreanin B
- Product Name
- EpiMedokoreanin B
- CAS No.
- 161068-53-7
- Chemical Name
- EpiMedokoreanin B
- Synonyms
- IcariinImpurity9;EpiMedokoreanin B;Icariin Impurity 8;Epimedokoreanin B, 10 mM in DMSO;2-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-
- CBNumber
- CB52654613
- Molecular Formula
- C25H26O6
- Formula Weight
- 422.47
- MOL File
- 161068-53-7.mol
EpiMedokoreanin B Property
- Boiling point:
- 665.9±55.0 °C(Predicted)
- Density
- 1.301±0.06 g/cm3(Predicted)
- pka
- 6.61±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CD32002289
- Product name
- EpimedokoreaninB
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $860
- Updated
- 2021/12/16
EpiMedokoreanin B Chemical Properties,Usage,Production
Uses
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3].
in vivo
Epimedokoreanin B (20 mg/kg; p.o; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model[4].
| Animal Model: | Female C3H mice (8-10 weeks old) injected with LM8 cells[4] |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration; thrice a week; for 17 days |
| Result: | Inhibited tumor growth. |
References
[1] Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263. DOI:10.1080/14786419.2018.1560283
[2] Hao Zheng, et al. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation. Chem Biol Interact. 2022 Oct 1;366:110125. DOI:10.1016/j.cbi.2022.110125
[3] T Kariu, et al. Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids. J Periodontal Res. 2017 Feb;52(1):89-96. DOI:10.1111/jre.12372
[4] Cheng Pan , et al. Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment. Front Pharmacol. 2020 Mar 18;11:262. DOI:10.3389/fphar.2020.00262
EpiMedokoreanin B Preparation Products And Raw materials
Raw materials
Preparation Products
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