NSC319726
- Product Name
- NSC319726
- CAS No.
- 71555-25-4
- Chemical Name
- NSC319726
- Synonyms
- ZMC1;CS-981;NSC319726;NSC319726 USP/EP/BP;NSC 319726;NSC-319726;N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide;N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide;1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide;Azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene] hydrazide;(E)-N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide
- CBNumber
- CB52655418
- Molecular Formula
- C11H14N4S
- Formula Weight
- 234.32
- MOL File
- 71555-25-4.mol
NSC319726 Property
- Melting point:
- 175-176 °C(Solv: acetonitrile (75-05-8))
- Boiling point:
- 367.7±34.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in H2O; ≥3.43 mg/mL in EtOH with gentle warming and ultrasonic; ≥8.1 mg/mL in DMSO
- form
- solid
- pka
- 11.52±0.20(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23701
- Product name
- NSC 319726
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 23701
- Product name
- NSC 319726
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2024/03/01
- Product number
- 23701
- Product name
- NSC 319726
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $385
- Updated
- 2024/03/01
- Product number
- 5065
- Product name
- NSC319726
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 5065
- Product name
- NSC319726
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $793
- Updated
- 2021/12/16
NSC319726 Chemical Properties,Usage,Production
Uses
NSC 319726 increases growth inhibitory activity in mutant p53 cells, particularly for the p53R175 mutant. NSC319726 is a p53R175 mutant reactivator and is a lead compound for p53-?targeted drug development.
Biological Activity
nsc 319726 is a reactivator of mutant p53 with ic50 value of 8nm [1].nsc 319726 belongs to the thiosemicarbazone family. in a mouse fibroblast cell line balb/c 3t3, nsc 319726 shows greater inhibition of cell growth in cells expressing mutant p53 than in wt p53 control. nsc 319726 is also nontoxic to wi38 human fibroblasts (p53 wt). in three different ovarian carcinoma cell lines (tov112d (p53r175h), ovcar3 (p53r248w) and skov3 (p53-/-)), treatment of nsc 319726 results in an induction of apoptosis in the p53r175 mutant. nsc 319726 restores p53 function through inducing a conformation change of mutant p53 to a “wt-like” structure which can be recognized by the wt specific antibody. the inhibition of cell growth caused by nsc 319726 is also found in the tov112d (p53r175h) xenografts when the dose of nsc 319726 is 1mg/kg. furthermore, it is shown that zinc ion chelation and ros changes are important for the apoptosis induced by nsc319726 [1].
References
[1] yu x, vazquez a, levine aj, carpizo dr. allele-specific p53 mutant reactivation. cancer cell. 2012 may 15;21(5):614-25.
NSC319726 Preparation Products And Raw materials
Raw materials
Preparation Products
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