Acethydrazide Property

Melting point:

58-68 °C (lit.)

Boiling point:

129 °C/18 mmHg (lit.)

Density 

1.0968 (rough estimate)

refractive index 

1.4264 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Moist Crystals and Chunks

pka

13.46±0.18(Predicted)

color 

White

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

506165

InChIKey

OFLXLNCGODUUOT-UHFFFAOYSA-N

CAS DataBase Reference

1068-57-1(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, hydrazide(1068-57-1)

EPA Substance Registry System

Acetic acid hydrazide (1068-57-1)

Safety

Hazard Codes 

Xn,T

Risk Statements 

22-36/38-68-40-25

Safety Statements 

26-36-45-36/37

RIDADR 

1759

WGK Germany 

1

RTECS 

AI1225000

F 

3-8-10

TSCA 

Y

HazardClass 

6.1

PackingGroup 

II

HS Code 

29280090

Toxicity

LD50 oral in bird - wild: 42200ug/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Acethydrazide Chemical Properties,Usage,Production

Description

Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2].

Chemical Properties

White moist crystals and chunks

Uses

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

Uses

Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.

Uses

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Definition

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.

Purification Methods

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

References

[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.