JIB-04

Product Name: JIB-04
CAS No.: 199596-05-9
Chemical Name: JIB-04
Synonyms: 5-chloro-n-[(e)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine;JIB-04;CS-1447;NSC 693627;JIB-04 (E);JIB04/JIB-04;JIB-04, >=98%;NSC693627 (E);JIB-04 USP/EP/BP;JIB-04 (NSC 693627)
CBNumber: CB52664368
Molecular Formula: C17H13ClN4
Formula Weight: 308.76
MOL File: 199596-05-9.mol

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JIB-04 Property

Boiling point:: 472.9±55.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 11.00±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey: YHHFKWKMXWRVTJ-OQKWZONESA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0808
Product name: JIB-04
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0808
Product name: JIB-04
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 15338
Product name: JIB-04
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 15338
Product name: JIB-04
Purity: ≥95%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 15338
Product name: JIB-04
Purity: ≥95%
Packaging: 25mg
Price: $278
Updated: 2024/03/01

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JIB-04 Chemical Properties,Usage,Production

Description

JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases?in vitro, in cancer cells and in tumors?in vivo.?IC50?= 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.??Reduces tumor burden and prolongs life in a mouse model.1?Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2?Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3

Uses

JIB-04 is a specific inhibitor of Jumonji demethylases.

Uses

JIB-04 has been used in sulforhodamine B cell growth assay. It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A).

Biochem/physiol Actions

JIB-04 is a selective inihibitor of Jumonji demethylases without inhibiting other α-ketoglutarate-dependent hydroxylases or histone-modifying enzymes including amine oxidase LSD1 (also known as KDM1A), which demethylates histone lysines. JIB-04 is a pan-inhibitor of Jumonji demethylases with JARID1A (KDM5A) being the most sensitive (IC50=230 nM) followed by JMJD2D (IC50=290 nM) and JMJD3 (KDM6B) and JMJD2C (KDM4C) more resistant (IC50 855 and 1100 nM, respectively). JIB-04 selectively inhibited viability of several human cancer cell lines with little toxicity towards normal cells, and also diminished tumor growth in two separate xenograft mouse models.

storage

+4°C

References

1) Wang?et al.?(2013),?A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth; Nature Commun., 4?2035

JIB-04 Preparation Products And Raw materials

Raw materials

Preparation Products

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JIB-04 Suppliers

China 92 India 1 United Kingdom 2 United States 16 Global 111

MedChemexpress LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

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Matrix Scientific

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View Lastest Price from JIB-04 manufacturers

Career Henan Chemical Co

Product: (E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE 199596-05-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 2kg
Release date: 2019-09-05

199596-05-9, JIB-04Related Search:

TYRPHOSTIN AG 879 Cantharidin 17-AAG Geldanamycin Pyridinethione 5-Chloro-2,3-difluoropyridine OXY-PYRION 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS BIX 01294 UNC-1215 GSK J4 HCl ABT 737 5-Carboxy-8-hydroxyquinoline Olaparib

JIB-04

JIB-04 (NSC 693627)

JIB04/JIB-04

5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone

(E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE

5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

NSC 693627

5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone JIB-04(NSC 693627)

JIB-04 5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone

(E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine

JIB-04 (NSC 693627)(E)

JIB-04, >=98%

NSC693627 (E)

JIB-04 (E)

5-chloro-n-[(e)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine

JIB-04 (NSC 693627), 199596-05-9(E)

CS-1447

JIB-04(NSC 693627), >97%

NSC693627;JIB04; JIB 04;NSC-693627;JIB-04;JIB04

Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (E,E)-

JIB-04 >=98% (HPLC)

JIB-04 USP/EP/BP

JIB-04 JHDM Inhibitor VII NSC 693627 JIB04

JIB-04,Apoptosis,JIB04,Inhibitor,Histone Demethylase,inhibit

199596-05-9

Inhibitors