ChemicalBook > CAS DataBase List > NVP BGJ398 phosphate

NVP BGJ398 phosphate

Product Name: NVP BGJ398 phosphate
CAS No.: 1310746-10-1
Chemical Name: NVP BGJ398 phosphate
Synonyms: BGJ-398 phosphate;BGJ 398 phosphate;NVP BGJ398 phosphate;NVP-BGJ398 (phosphate);Infigratinib phosphate;BGJ-398,NVP-BGJ398,Infigratinib;Infigratinib (BGJ-398) phosphate;Infigratinib phosphate, 10 mM in DMSO;INFIGRATINIB PHOSPHATE;BGJ-398 PHOSPHATE;NVP-BGJ398 phosphate (Infigratinib phosphate
CBNumber: CB52666670
Molecular Formula: C26H34Cl2N7O7P
Formula Weight: 658.47
MOL File: 1310746-10-1.mol

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NVP BGJ398 phosphate Property

storage temp.: Store at -20°C
solubility: insoluble in EtOH; ≥28.07 mg/mL in H2O with gentle warming and ultrasonic; ≥95.7 mg/mL in DMSO
form: Powder
color: White to gray
InChIKey: GUQNHCGYHLSITB-UHFFFAOYSA-N
SMILES: P(O)(O)(O)=O.N(C1C(=C(OC)C=C(OC)C=1Cl)Cl)C(=O)N(C1=NC=NC(NC2C=CC(N3CCN(CC)CC3)=CC=2)=C1)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1559
Product name: Infigratinibphosphate
Purity: 97.74%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611817
Product name: NVP-BGJ398 phosphate
Packaging: 10mg
Price: $217.6
Updated: 2021/12/16

ChemScene

Product number: CS-1559
Product name: Infigratinibphosphate
Purity: 97.74%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611817
Product name: NVP-BGJ398 phosphate
Packaging: 50mg
Price: $385.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611817
Product name: NVP-BGJ398 phosphate
Packaging: 100mg
Price: $482.8
Updated: 2021/12/16

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NVP BGJ398 phosphate Chemical Properties,Usage,Production

Uses

Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

Biological Activity

ic50 value: 0.9 nm (fgfr1); 1.4 nm (fgfr2); 1 nm (fgfr2) [1] nvp-bgj398 is a novel selective, pan-specific fgfr inhibitor currently in phase i

in vivo

Infigratinib is administered to athymic nude mice implanted subcutaneously with RT112/luc1 tumors: either as a 5 mg/kg intravenous bolus in NMP/PEG200 (1:9, v/v) or orally by gavage as a suspension in PEG300/D5W (2:1, v/v) at a 20 mg/kg dose. The relevant pharmacokinetic (PK) parameters indicate that the oral bioavailability of Infigratinib in this study is 32%. After intravenous dosing, Infigratinib shows a rapid distribution from the vascular compartment into the peripheral tissues, translating into a high volume of distribution (26 L/kg). The plasma clearance is high at 3.3 L/h/kg (61% of liver blood flow). The ratio of tumor to plasma after oral dosing based on AUC is determined to be 10^[1]. Infigratinib (30 mg/kg) significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models^[2].

IC 50

FGFR1: 0.9 nM (IC₅₀); FGFR2: 1.4 nM (IC₅₀); FGFR3: 1 nM (IC₅₀); FGFR4: 60 nM (IC₅₀)

References

[1] Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T DOI:10.1021/jm2006222
[2] Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. DOI:10.1158/1535-7163.MCT-12-0999

NVP BGJ398 phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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1310746-10-1, NVP BGJ398 phosphateRelated Search:

Infigratinib LMI070 N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine NVS-PAK1-1 NVP-BSK805 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide NVP-CGM097

INFIGRATINIB PHOSPHATE;BGJ-398 PHOSPHATE

BGJ-398 PHOSPHATE; BGJ 398 PHOSPHATE; NVP BGJ398 PHOSPHATE

BGJ 398 phosphate

BGJ-398 phosphate

NVP BGJ398 phosphate

NVP-BGJ398 (phosphate)

N'-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methylurea phosphate (1:1)

BGJ-398,NVP-BGJ398,Infigratinib

Infigratinib phosphate

Infigratinib (BGJ-398) phosphate

3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate

Infigratinib phosphate, 10 mM in DMSO

NVP-BGJ398 phosphate (Infigratinib phosphate

1310746-10-1

C26H34Cl2N7O7P

C26H31Cl2N7O3H3PO4