ChemicalBook > CAS DataBase List > 2-Acetylfuro-1,4-naphthoquinone

2-Acetylfuro-1,4-naphthoquinone

Product Name: 2-Acetylfuro-1,4-naphthoquinone
CAS No.: 83280-65-3
Chemical Name: 2-Acetylfuro-1,4-naphthoquinone
Synonyms: 139057;CS-945;BBI-606;Napabucasin;Napabucasin Impurity;Remimazolam besylate;Napabucasin (BBI608);Napabucasin, 10 mM in DMSO;Napabucasin (BBI608) ，S7977;2-Acetylfuro-1,4-phthoquinone
CBNumber: CB52667637
Molecular Formula: C14H8O4
Formula Weight: 240.21
MOL File: 83280-65-3.mol

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2-Acetylfuro-1,4-naphthoquinone Property

Melting point:: 225-226℃ (dichloromethane )
Boiling point:: 444.4±45.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 20 mg/ml)
form: Brown solid
color: Yellow
λmax: 272nm(EtOH)(lit.)
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
InChIKey: DPHUWDIXHNQOSY-UHFFFAOYSA-N
SMILES: O1C(C(C)=O)=CC2C(=O)C3=C(C(=O)C1=2)C=CC=C3

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Safety

HS Code: 2932.99.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33851
Product name: Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem
Packaging: 10mg
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: A3110
Product name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity: >98.0%(GC)
Packaging: 25mg
Price: $165
Updated: 2025/07/31

TCI Chemical

Product number: A3110
Product name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity: >98.0%(GC)
Packaging: 100mg
Price: $457
Updated: 2025/07/31

Cayman Chemical

Product number: 22255
Product name: Napabucasin
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22255
Product name: Napabucasin
Purity: ≥98%
Packaging: 10mg
Price: $116
Updated: 2024/03/01

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2-Acetylfuro-1,4-naphthoquinone Chemical Properties,Usage,Production

Description

Napabucasin is an inhibitor of cancer cell stemness. It reduces growth in a panel of cancer cells enriched for high stemness (IC₅₀s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.

Uses

Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.

in vivo

Napabucasin (40 mg/kg) or Docetaxel significantly reduces xenograft tumor growth and tumor volume (TV) compared with PBS (P<0.05). Notably, while no differences are observed between the Napabucasin and the docetaxel groups in PC-3 mouse xenograft models, the TV in Napabucasin group is even lower than docetaxel group in 22RV1 mouse xenograft models (P<0.05). Additionally, Napabucasin or docetaxel also significantly reduces tumor weight compared with PBS (P<0.05)^[1].

IC 50

STAT3

storage

Store at -20°C

References

[1] YOUZHI LI. Suppression of cancer relapse and metastasis by inhibiting cancer stemness.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015: 1839-1844. DOI:10.1073/pnas.1424171112
[2] JOLEEN M HUBBARD Axel G. Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor.[J]. Drugs, 2017, 77 10: 1091-1103. DOI:10.1007/s40265-017-0759-4
[3] YIMING ZHANG. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin[J]. Cancer Medicine, 2016, 5 6: 1251-1258. DOI:10.1002/cam4.675
[4] LAUREN MACDONAGH . BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC[J]. Cancer letters, 2018, 428: Pages 117-126. DOI:10.1016/j.canlet.2018.04.008

2-Acetylfuro-1,4-naphthoquinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Acetylfuro-1,4-naphthoquinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Napabucasin 83280-65-3
Price: US $2.00-6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-ton
Release date: 2025-07-28

Shaanxi Dideu Medichem Co. Ltd

Product: Napabucasin 83280-65-3
Price: US $1.20/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 10 tons min
Release date: 2022-10-09

PNP Biotech Co. Ltd

Product: Napabucasin(BBI-608) 83280-65-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

83280-65-3, 2-Acetylfuro-1,4-naphthoquinoneRelated Search:

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2-Acetylfuro-1,4-naphthoquinone

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Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem

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CS-945

inhibit,BBI 608,BBI-608,Inhibitor,STAT,Napabucasin

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Cancer Stemness Inhibitor, BBI608

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83280-65-3