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2-Acetylfuro-1,4-naphthoquinone

Product Name
2-Acetylfuro-1,4-naphthoquinone
CAS No.
83280-65-3
Chemical Name
2-Acetylfuro-1,4-naphthoquinone
Synonyms
139057;CS-945;BBI-606;Napabucasin;Napabucasin Impurity;Remimazolam besylate;Napabucasin (BBI608);2-Acetylfuro-1,4-phthoquinone;2-Acetylfuro-1,4-naphthoquinone;2-acetylnaphtho[2,3-b]furan-4,9-quinone
CBNumber
CB52667637
Molecular Formula
C14H8O4
Formula Weight
240.21
MOL File
83280-65-3.mol
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2-Acetylfuro-1,4-naphthoquinone Property

Melting point:
225-226℃ (dichloromethane )
Boiling point:
444.4±45.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
Soluble in DMSO (up to 20 mg/ml)
form 
Brown solid
color 
Yellow
λmax
272nm(EtOH)(lit.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2932.99.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.33851
Product name
Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem
Packaging
10mg
Price
$129
Updated
2024/03/01
TCI Chemical
Product number
A3110
Product name
2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity
>98.0%(GC)
Packaging
25mg
Price
$165
Updated
2024/03/01
TCI Chemical
Product number
A3110
Product name
2-Acetylnaphtho[2,3-b]furan-4,9-dione
Purity
>98.0%(GC)
Packaging
100mg
Price
$457
Updated
2024/03/01
Cayman Chemical
Product number
22255
Product name
Napabucasin
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
22255
Product name
Napabucasin
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
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2-Acetylfuro-1,4-naphthoquinone Chemical Properties,Usage,Production

Description

Napabucasin is an inhibitor of cancer cell stemness. It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.

Uses

Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.

storage

Store at -20°C

References

1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839 2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemness Inhibitor; Drugs, 77 1091 3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251 4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117

2-Acetylfuro-1,4-naphthoquinone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Acetylfuro-1,4-naphthoquinone Suppliers

Americas 1 China 117 Europe 1 India 2 Japan 1 The Netherlands 1 United Kingdom 1 United States 15 Global 139
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from 2-Acetylfuro-1,4-naphthoquinone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Napabucasin 83280-65-3
Price
US $1.20/g
Min. Order
1g
Purity
99.0% min
Supply Ability
10 tons min
Release date
2022-10-09
PNP Biotech Co. Ltd
Product
Napabucasin(BBI-608) 83280-65-3
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16
Career Henan Chemical Co
Product
2-Acetylfuro-1,4-naphthoquinone 83280-65-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

83280-65-3, 2-Acetylfuro-1,4-naphthoquinoneRelated Search:

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  • 2-Acetylfuro-1,4-naphthoquinone
  • Napabucasin
  • 2-Acetylfuro-1,4-phthoquinone
  • Napabucasin (BBI608)
  • 2-acetylnaphtho[2,3-b]furan-4,9-quinone
  • Remimazolam besylate
  • Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-
  • 2-acetylbenzo[f][1]benzofuran-4,9-dione
  • 139057
  • Napabucasin Impurity
  • Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem
  • BBI-606
  • CS-945
  • inhibit,BBI 608,BBI-608,Inhibitor,STAT,Napabucasin
  • Cancer cell stemness inhibitor (Napabucasin)
  • 83280-65-3