DESACETYLVINBLASTINEAMIDE

Product Name: DESACETYLVINBLASTINEAMIDE
CAS No.: 53643-48-4
Chemical Name: DESACETYLVINBLASTINEAMIDE
Synonyms: VINDESINE;VDS;Fildesin;Eldesine;Compound-112531;VINDESINE SULFATE(RG);DESACETYLVINBLASTINEAMIDE;DESACETYLVINBLASTINEAMIDE USP/EP/BP;Compound 112531：NS C．245467：LY-099094：Hdisine：Fildisin;3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
CBNumber: CB5266881
Molecular Formula: C43H55N5O7
Formula Weight: 753.93
MOL File: 53643-48-4.mol

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DESACETYLVINBLASTINEAMIDE Property

Melting point:: 230-232°
alpha: D25 +39.4° (c = 1.0 in methanol)
Density: 1.41±0.1 g/cm3(Predicted)
pka: pKa (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67(at 25℃)

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Safety

RIDADR: 1544
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 53643-48-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 291976
Product name: Vindesine
Packaging: 250mg
Price: $1346
Updated: 2021/12/16

AvaChem

Product number: 2181B
Product name: Vindesine
Packaging: 250mg
Price: $1750
Updated: 2021/12/16

AvaChem

Product number: 2181B
Product name: Vindesine
Packaging: 1g
Price: $4750
Updated: 2021/12/16

AvaChem

Product number: 2181B
Product name: Vindesine
Packaging: 5mg
Price: $65
Updated: 2021/12/16

AvaChem

Product number: 2181B
Product name: Vindesine
Packaging: 10mg
Price: $115
Updated: 2021/12/16

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DESACETYLVINBLASTINEAMIDE Chemical Properties,Usage,Production

Originator

Eldisine,Lilly ,France,1980

Uses

Antineoplastic.

Definition

ChEBI: Vindesine is a vinca alkaloid, a methyl ester, an organic heterotetracyclic compound, an organic heteropentacyclic compound, a tertiary alcohol, a tertiary amino compound and a primary carboxamide. It has a role as an antineoplastic agent. It is functionally related to a vincaleukoblastine.

Manufacturing Process

About 10 g of VLB (vincaleucoblastine or simply vinblastine) sulfate were converted by standard procedures to VLB free base. The free base, obtained as a residue after evaporation of the dried ethereal solvent, was dissolved in about 200 ml of anhydrous methanol. Anhydrous liquid ammonia (300 ml) was added, and the reaction mixture sealed and maintained at about 100°C for 60 hours. The reaction vessel was opened, and the contents removed and evaporated to dryness in vacuo. The resulting residue, containing 4-desacetyI VLB C-3 carboxamide, as shown by thin layer chromatography, were combined and the solvent evaporated therefrom in vacuo, yielding asa residue purified 4-desacetyl VLB C-3 carboxamide free base. The NMR and IR spectra of the solid free base confirmed the structure indicated. The free base showed a band in the infrared at 1,687 cm -l , characteristic of the amide function. The molecular weight of the free base determined by mass spectroscopy was 753 which is in agreement with theoretical value calculated for C 43 H 55 N 5 O 7 .

brand name

Eldisine (Lilly).

Therapeutic Function

Antineoplastic

DESACETYLVINBLASTINEAMIDE Preparation Products And Raw materials

Raw materials

1-Butyl nitrite Vinblastine sulfate Dichloromethane HYDRAZINE Methanol Triphenylphosphine Vincristine sulfate Ammonia

Preparation Products

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DESACETYLVINBLASTINEAMIDE Suppliers

China 59 Europe 2 United Kingdom 1 United States 13 Global 75

EMMX Biotechnology LLC

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QVENTAS INC.

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View Lastest Price from DESACETYLVINBLASTINEAMIDE manufacturers

Dideu Industries Group Limited

Product: DESACETYLVINBLASTINEAMIDE 53643-48-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

Shaanxi Dideu Medichem Co. Ltd

Product: Vindesine 53643-48-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

53643-48-4, DESACETYLVINBLASTINEAMIDERelated Search:

Vinblastine sulfate Vincristine Dexrazoxane Vinorelbine tartrate Vindesine sulfate 1,3,3,5,5-PENTAMETHYLCYCLOHEXANOL TRIMETHYLHEXAMETHYLENEDIAMINE TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL DESACETYLVINBLASTINEAMIDE P-(TRANS-4-HYDROXYCYCLOHEXYL)PHENOL (2-METHOXY-5-METHYLPHENYL)ACETIC ACID TRANS-2-HYDROXY-1-CYCLOHEXANECARBOXAMIDE CIS-2-AMINO-1-CYCLOHEXANECARBOXAMIDE 1-(2-(2-Methyl-1H-indol-3-yl)ethyl)-3-piperidinol 2-METHOXY-5-METHYL-BENZENEACETIC ACID METHYL ESTER Propionic acid, 2-(4-(isopropylamino)phenyl)- 2-Methyl-3-(2-(3-methyl-1-piperidinyl)ethyl)-1H-indole 2,4-BIS(1-METHYLBUTYL)PHENOL

VINDESINE

3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastin

3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine

DESACETYLVINBLASTINEAMIDE

Fildesin

Compound 112531：NS C．245467：LY-099094：Hdisine：Fildisin

VDS

Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-

VINDESINE SULFATE(RG)

3-(Aminocarbonyl)-O^<4>^-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine

3-(Aminocarbonyl)-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine

3-Carbamoyl-4-O-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine

Compound-112531

Eldesine

DESACETYLVINBLASTINEAMIDE USP/EP/BP

53643-48-4

C43H55N5O7