ChemicalBook > CAS DataBase List > (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
- Product Name
- (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
- CAS No.
- 1185503-48-3
- Chemical Name
- (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
- Synonyms
- Aprepitant intermediate 1;Fosaprepitant Impurity 31;Aprepitant Impurity 12 HCl;Aprepitant intermediate 1 HCl;Arepitam intermediate 1 hydrochloride;Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe;Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
- CBNumber
- CB52669000
- Molecular Formula
- C20H18F7NO2
- Formula Weight
- 437.35
- MOL File
- 1185503-48-3.mol
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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Property
- Boiling point:
- 387.9±42.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- pka
- 6.93±0.60(Predicted)
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N-Bromosuccinimide Price
TRC
- Product number
- D297835
- Product name
- Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
TRC
- Product number
- D297835
- Product name
- Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant
- Packaging
- 5mg
- Price
- $235
- Updated
- 2021/12/16
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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Chemical Properties,Usage,Production
Uses
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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1185503-48-3, (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochlorideRelated Search:
Fosaprepitant Impurity 6
[2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
Aprepitant
Fosaprepitant Impurity 5
5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one
(S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one
1,1,1-Trimethoxy-2-chloroethane
Aprepitant
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
Benzyl dihydrogen phosphate
(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
Aprepitant
Aprepitant
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
Aprepitant Impurity 17