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CW069

Product Name
CW069
CAS No.
1594094-64-0
Chemical Name
CW069
Synonyms
CW069;CS-1425;CW069; CW 069;CW069 USP/EP/BP;CW-069,Inhibitor,Kinesin,inhibit,CW 069;(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID;2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
CBNumber
CB52681121
Molecular Formula
C23H21IN2O3
Formula Weight
500.33
MOL File
1594094-64-0.mol
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CW069 Property

Boiling point:
666.0±55.0 °C(Predicted)
Density 
1.559±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
form 
solid
pka
2.69±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22936
Product name
CW069
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
22936
Product name
CW069
Purity
≥95%
Packaging
5mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
22936
Product name
CW069
Purity
≥95%
Packaging
10mg
Price
$356
Updated
2024/03/01
TRC
Product number
C857000
Product name
CW069
Packaging
25mg
Price
$1075
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181226
Product name
CW069
Purity
>98%
Packaging
250mg
Price
$1208.7
Updated
2021/12/16
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CW069 Chemical Properties,Usage,Production

Description

CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).

Uses

CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.

References

[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.

CW069 Preparation Products And Raw materials

Raw materials

Preparation Products

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CW069 Suppliers

China 61 India 1 United States 15 Global 77
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 333-9607
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info@adooq.com
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857-239-0968
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service1@targetmol.com
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+1-800-259-7612
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
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sales@cckinase.com
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United States
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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United States Biological
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Cayman Chemical Company
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Combi-Blocks Inc.
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1594094-64-0, CW069Related Search:

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  • CW069
  • CW069; CW 069
  • CS-1425
  • (S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID
  • 5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid
  • Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
  • 2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid
  • CW069 USP/EP/BP
  • CW-069,Inhibitor,Kinesin,inhibit,CW 069
  • 1594094-64-0
  • Inhibitors