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(-)-Pinoresinol 4-O-glucoside

Product Name
(-)-Pinoresinol 4-O-glucoside
CAS No.
41607-20-9
Chemical Name
(-)-Pinoresinol 4-O-glucoside
Synonyms
(-)-Pinoresinol glucoside;(-)-pinoresinol glucoside;Pinoresinol beta-D-glucopyranoside;β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl
CBNumber
CB52681141
Molecular Formula
C26H32O11
Formula Weight
520.53
MOL File
41607-20-9.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot
Product number
CD32001445
Product name
(-)-Pinoresinol4-O-glucoside
Purity
95+%
Packaging
5mg
Price
$730
Updated
2021/12/16
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(-)-Pinoresinol 4-O-glucoside Chemical Properties,Usage,Production

Uses

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 μM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

Definition

ChEBI: (-)-Pinoresinol glucoside is a glycoside and a lignan.

in vivo

(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2].

Animal Model:27-30 g, Male Swiss albino mice[2]
Dosage:50 mg/kg
Administration:P.o.; twenty days
Result:Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.

References

[1] Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. DOI:10.3390/ijms21249579
[2] Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. DOI:10.1111/jphp.13358

(-)-Pinoresinol 4-O-glucoside Preparation Products And Raw materials

Raw materials

Preparation Products

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41607-20-9, (-)-Pinoresinol 4-O-glucosideRelated Search:

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  • Pinoresinol beta-D-glucopyranoside
  • (-)-pinoresinol glucoside
  • β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl
  • (-)-Pinoresinol glucoside
  • 41607-20-9