ChemicalBook > CAS DataBase List > MK-4827 (tosylate)

MK-4827 (tosylate)

Product Name
MK-4827 (tosylate)
CAS No.
1038915-73-9
Chemical Name
MK-4827 (tosylate)
Synonyms
Niraparib Tosylate;Niraparib TOS;Niraparib TsOH;MK-4827 (tosylate);Niraparib Tosilate;Niraparib(MK-4827) tosylate;MK-4827(Niraparib) tosylate;niraparib p-toluenesulfonate;MK-4827, Niraparib TsOH salt;Niraparib Tosylate (MK-4827)
CBNumber
CB52682012
Molecular Formula
C26H28N4O4S
Formula Weight
492.58992
MOL File
1038915-73-9.mol
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MK-4827 (tosylate) Property

Melting point:
>142oC (dec.)
storage temp. 
-20°C Freezer
solubility 
Methanol (Slightly)
form 
Solid
color 
Off-White to Pale Yellow
InChI
InChI=1/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/s3
InChIKey
LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES
S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20842
Product name
MK-4827 (tosylate)
Purity
≥98%
Packaging
5mg
Price
$46
Updated
2024/03/01
Cayman Chemical
Product number
20842
Product name
MK-4827 (tosylate)
Purity
≥98%
Packaging
50 mg
Price
$253
Updated
2024/03/01
Cayman Chemical
Product number
20842
Product name
MK-4827 (tosylate)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2023/01/06
Cayman Chemical
Product number
20842
Product name
MK-4827 (tosylate)
Purity
≥98%
Packaging
10mg
Price
$83
Updated
2024/03/01
Cayman Chemical
Product number
20842
Product name
MK-4827 (tosylate)
Purity
≥98%
Packaging
25mg
Price
$149
Updated
2024/03/01
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MK-4827 (tosylate) Chemical Properties,Usage,Production

Description

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.

Uses

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

in vitro

In a whole-cell assay, Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC50=4 nM and EC90=45 nM. Niraparib tosylate hydrate inhibits the proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole-cell assay. Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment, reaching about 85% inhibition in the A549 cells at 1 h and about 55% inhibition at 1 h for the H1299 cells.

MK-4827 (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-4827 (tosylate) Suppliers

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View Lastest Price from MK-4827 (tosylate) manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
MK-4827 (tosylate) 1038915-73-9
Price
US $20.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-17
Zibo Hangyu Biotechnology Development Co., Ltd
Product
MK-4827 (tosylate) 1038915-73-9
Price
US $0.10-0.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
20n tons
Release date
2024-02-16
Henan Aochuang Chemical Co.,Ltd.
Product
Niraparib tosylate 2191-20-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22

1038915-73-9, MK-4827 (tosylate)Related Search:

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  • Niraparib TsOH
  • niraparib p-toluenesulfonate
  • MK-4827(Niraparib) tosylate
  • Niraparib Tosylate
  • MK-4827 (tosylate)
  • (3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate
  • MK-4827, Niraparib TsOH salt
  • Niraparib(MK-4827) tosylate
  • NIRAPARIB TOSYLATE;MK 4827 TOSYLATE;MK4827 TOSYLATE
  • 2H-Indazole-7-carboxamide,2-[4-[(3S)-3-piperidinyl]phenyl]-,4-methylbenzenesulfonate(1:1)
  • Niraparib TOS
  • MK-4827 (tosylate) ISO 9001：2015 REACH
  • Niraparib Tosylate (MK-4827)
  • (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate
  • Niraparib tosylate monohydrate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-isoindole-4-carboxamide compound with 1-methyl-4-(methylsulfonyl)benzene (1:1) hydrate
  • Niraparib Tosilate
  • 1038915-73-9
  • C19H20N4OC7H8O3S